A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum

A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum

BACKGROUND Despite treatment with effective antimalarial drugs, the mortality rate is still high in severe cases of the disease, highlighting the need to find adjunct therapies that can inhibit the adhesion of Plasmodium falciparum-infected erythrocytes (Pf-iEs). OBJECTIVES In this context, we ev...

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Bibliographic Details
Main Authors: Marcele F Bastos, Letusa Albrecht, Angélica M Gomes, Stefanie CP Lopes, Cristina P Vicente, Rodrigo PM de Almeida, Gustavo C Cassiano, Roberto JC Fonseca, Claudio C Werneck, Mauro SG Pavão, Fabio TM Costa
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
glycosaminoglycan
severe malaria
adhesion
antimalarial
adjuvant therapy
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100333&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100333&lng=en&tlng=en

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