A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
BACKGROUND Despite treatment with effective antimalarial drugs, the mortality rate is still high in severe cases of the disease, highlighting the need to find adjunct therapies that can inhibit the adhesion of Plasmodium falciparum-infected erythrocytes (Pf-iEs). OBJECTIVES In this context, we ev...
Main Authors: | Marcele F Bastos, Letusa Albrecht, Angélica M Gomes, Stefanie CP Lopes, Cristina P Vicente, Rodrigo PM de Almeida, Gustavo C Cassiano, Roberto JC Fonseca, Claudio C Werneck, Mauro SG Pavão, Fabio TM Costa |
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Format: | Article |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
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Series: | Memórias do Instituto Oswaldo Cruz. |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762019000100333&lng=en&tlng=en |
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