Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression
Background: Obstructive sleep apnea syndrome (OSAS) is associated with a variety of inflammatory factors. Specifically, proinflammatory cytokines appear to be associated with the pathogenesis of OSAS. Methods: For the present meta-analysis and meta-regression on serum and plasma tumor necrosis facto...
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doaj-e48175af14c344d2b73c933d6524f2ba2020-11-25T03:47:54ZengMDPI AGLife2075-17292020-06-0110878710.3390/life10060087Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-RegressionMohammad Moslem Imani0Masoud Sadeghi1Habibolah Khazaie2Mehrdad Emami3Dena Sadeghi Bahmani4Serge Brand5Department of Orthodontics, Kermanshah University of Medical Sciences, 6713954658 Kermanshah, IranMedical Biology Research Center, Kermanshah University of Medical Sciences, 6714415185 Kermanshah, IranSleep Disorders Research Center, Kermanshah University of Medical Sciences, 6719851115 Kermanshah, IranStudents Research Committee, Kermanshah University of Medical Sciences, 6715847141 Kermanshah, IranSleep Disorders Research Center, Kermanshah University of Medical Sciences, 6719851115 Kermanshah, IranSleep Disorders Research Center, Kermanshah University of Medical Sciences, 6719851115 Kermanshah, IranBackground: Obstructive sleep apnea syndrome (OSAS) is associated with a variety of inflammatory factors. Specifically, proinflammatory cytokines appear to be associated with the pathogenesis of OSAS. Methods: For the present meta-analysis and meta-regression on serum and plasma tumor necrosis factor alpha (TNF-α) levels in individuals with and without OSAS, we performed a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases to find relevant articles published up to February 1, 2020. Results: Fifty-five (adults: 29 studies on serum and 17 studies on plasma; children: 4 studies on serum and 5 studies on plasma) were included and analyzed. Always compared to age-matched healthy controls, the pooled MDs were as follows: adults, serum: 10.22 pg/mL (95% CI = 8.86, 11.58; <i>p</i> < 0.00001); adults, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; <i>p</i> < 0.00001); children, serum: 0.21 pg/mL (95% CI = 0.05, 0.37; <i>p</i> = 0.01); children, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; <i>p</i> < 0.00001). Conclusions: Compared to healthy and age-matched controls, adult individuals with OSAS had significantly higher serum/plasma TNF-α levels. For children with OSAS, significantly higher levels were observed for TNF-α in serum but not in plasma.https://www.mdpi.com/2075-1729/10/6/87obstructive sleep apnea syndromecytokinetumor necrosis factor alphaserumplasmameta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Moslem Imani Masoud Sadeghi Habibolah Khazaie Mehrdad Emami Dena Sadeghi Bahmani Serge Brand |
spellingShingle |
Mohammad Moslem Imani Masoud Sadeghi Habibolah Khazaie Mehrdad Emami Dena Sadeghi Bahmani Serge Brand Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression Life obstructive sleep apnea syndrome cytokine tumor necrosis factor alpha serum plasma meta-analysis |
author_facet |
Mohammad Moslem Imani Masoud Sadeghi Habibolah Khazaie Mehrdad Emami Dena Sadeghi Bahmani Serge Brand |
author_sort |
Mohammad Moslem Imani |
title |
Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression |
title_short |
Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression |
title_full |
Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression |
title_fullStr |
Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression |
title_full_unstemmed |
Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression |
title_sort |
serum and plasma tumor necrosis factor alpha levels in individuals with obstructive sleep apnea syndrome: a meta-analysis and meta-regression |
publisher |
MDPI AG |
series |
Life |
issn |
2075-1729 |
publishDate |
2020-06-01 |
description |
Background: Obstructive sleep apnea syndrome (OSAS) is associated with a variety of inflammatory factors. Specifically, proinflammatory cytokines appear to be associated with the pathogenesis of OSAS. Methods: For the present meta-analysis and meta-regression on serum and plasma tumor necrosis factor alpha (TNF-α) levels in individuals with and without OSAS, we performed a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases to find relevant articles published up to February 1, 2020. Results: Fifty-five (adults: 29 studies on serum and 17 studies on plasma; children: 4 studies on serum and 5 studies on plasma) were included and analyzed. Always compared to age-matched healthy controls, the pooled MDs were as follows: adults, serum: 10.22 pg/mL (95% CI = 8.86, 11.58; <i>p</i> < 0.00001); adults, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; <i>p</i> < 0.00001); children, serum: 0.21 pg/mL (95% CI = 0.05, 0.37; <i>p</i> = 0.01); children, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; <i>p</i> < 0.00001). Conclusions: Compared to healthy and age-matched controls, adult individuals with OSAS had significantly higher serum/plasma TNF-α levels. For children with OSAS, significantly higher levels were observed for TNF-α in serum but not in plasma. |
topic |
obstructive sleep apnea syndrome cytokine tumor necrosis factor alpha serum plasma meta-analysis |
url |
https://www.mdpi.com/2075-1729/10/6/87 |
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