Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using <i>Pparβ</i>/<i>δ</i>-Deficient Mice
Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroida...
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doaj-e482dcb139fb4420bc9fc2a22d45490e2020-11-25T03:20:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-01214403440310.3390/ijms21124403Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using <i>Pparβ</i>/<i>δ</i>-Deficient MiceSze Yuan Ho0Yuet Ping Kwan1Beiying Qiu2Alison Tan3Hannah Louise Murray4Veluchamy Amutha Barathi5Nguan Soon Tan6Chui Ming Gemmy Cheung7Tien Yin Wong8Walter Wahli9Xiaomeng Wang10Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 59 Nanyang Drive, Singapore 636921, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 59 Nanyang Drive, Singapore 636921, SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Dr., Singapore 138673, SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Dr., Singapore 138673, SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Dr., Singapore 138673, SingaporeSingapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 59 Nanyang Drive, Singapore 636921, SingaporeSingapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856, SingaporeSingapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower Level 6, Singapore 169856, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 59 Nanyang Drive, Singapore 636921, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 59 Nanyang Drive, Singapore 636921, SingaporePeroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in <i>Pparβ</i>/<i>δ</i>-deficient mice. However, PPARβ/δ’s role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in <i>Pparβ</i>/<i>δ</i>-haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina.https://www.mdpi.com/1422-0067/21/12/4403PPARβ/δangiogenesisblood vessel remodelingpericytesvessel caliberarteriovenous crossover |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sze Yuan Ho Yuet Ping Kwan Beiying Qiu Alison Tan Hannah Louise Murray Veluchamy Amutha Barathi Nguan Soon Tan Chui Ming Gemmy Cheung Tien Yin Wong Walter Wahli Xiaomeng Wang |
spellingShingle |
Sze Yuan Ho Yuet Ping Kwan Beiying Qiu Alison Tan Hannah Louise Murray Veluchamy Amutha Barathi Nguan Soon Tan Chui Ming Gemmy Cheung Tien Yin Wong Walter Wahli Xiaomeng Wang Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using <i>Pparβ</i>/<i>δ</i>-Deficient Mice International Journal of Molecular Sciences PPARβ/δ angiogenesis blood vessel remodeling pericytes vessel caliber arteriovenous crossover |
author_facet |
Sze Yuan Ho Yuet Ping Kwan Beiying Qiu Alison Tan Hannah Louise Murray Veluchamy Amutha Barathi Nguan Soon Tan Chui Ming Gemmy Cheung Tien Yin Wong Walter Wahli Xiaomeng Wang |
author_sort |
Sze Yuan Ho |
title |
Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using <i>Pparβ</i>/<i>δ</i>-Deficient Mice |
title_short |
Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using <i>Pparβ</i>/<i>δ</i>-Deficient Mice |
title_full |
Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using <i>Pparβ</i>/<i>δ</i>-Deficient Mice |
title_fullStr |
Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using <i>Pparβ</i>/<i>δ</i>-Deficient Mice |
title_full_unstemmed |
Investigating the Role of PPARβ/δ in Retinal Vascular Remodeling Using <i>Pparβ</i>/<i>δ</i>-Deficient Mice |
title_sort |
investigating the role of pparβ/δ in retinal vascular remodeling using <i>pparβ</i>/<i>δ</i>-deficient mice |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-06-01 |
description |
Peroxisome proliferator-activated receptor (PPAR)β/δ is a member of the nuclear receptor superfamily of transcription factors, which plays fundamental roles in cell proliferation and differentiation, inflammation, adipogenesis, and energy homeostasis. Previous studies demonstrated a reduced choroidal neovascularization (CNV) in <i>Pparβ</i>/<i>δ</i>-deficient mice. However, PPARβ/δ’s role in physiological blood vessel formation and vessel remodeling in the retina has yet to be established. Our study showed that PPARβ/δ is specifically required for disordered blood vessel formation in the retina. We further demonstrated an increased arteriovenous crossover and wider venous caliber in <i>Pparβ</i>/<i>δ</i>-haplodeficient mice. In summary, these results indicated a critical role of PPARβ/δ in pathological angiogenesis and blood vessel remodeling in the retina. |
topic |
PPARβ/δ angiogenesis blood vessel remodeling pericytes vessel caliber arteriovenous crossover |
url |
https://www.mdpi.com/1422-0067/21/12/4403 |
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