Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy
Background and objectives: We assessed correlations between the resting state functional connectivity (RSFC) of different thalamic nuclei and seizure frequency in patients with drug-resistant medial temporal lobe epilepsy (mTLE). Methods: Seventeen patients with mTLE and 17 sex-/age-/handedness-matc...
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doaj-e488c88f7c814e4ebb3031d5a1d884552020-11-24T21:37:01ZengElsevierNeuroImage: Clinical2213-15822019-01-0121Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsyHang Joon Jo0Daniel L. Kenny-Jung1Irena Balzekas2Eduardo E. Benarroch3David T. Jones4Benjamin H. Brinkmann5S. Matt Stead6Jamie J. Van Gompel7Kirk M. Welker8Gregory A. Worrell9Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USA; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA; Corresponding authors at: 200 First Street SW, Rochester, MN 55905, USA.Department of Neurology, Mayo Clinic, Rochester, MN 55905, USADepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USADepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USADepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USADepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Department of Biomedical Engineering and Physiology, Mayo Clinic, Rochester, MN 55905, USADepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USADepartment of Neurologic Surgery, Mayo Clinic, Rochester, MN 55905, USADepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USADepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Corresponding authors at: 200 First Street SW, Rochester, MN 55905, USA.Background and objectives: We assessed correlations between the resting state functional connectivity (RSFC) of different thalamic nuclei and seizure frequency in patients with drug-resistant medial temporal lobe epilepsy (mTLE). Methods: Seventeen patients with mTLE and 17 sex-/age-/handedness-matched controls participated. A seed-based correlation method for the resting-state FMRI data was implemented to get RSFC maps of 70 thalamic nuclei seed masks. Group statistics for individual RSFC for subjects and seed masks were performed to obtain within-group characteristics and between-group differences with age covariates. A linear regression was applied to test whether seizure frequency correlated with thalamic nuclear RSFC with the whole brain in mTLE patients. Results: RSFC of thalamic nuclei showed spatially distinguishable connectivity patterns that reflected principal inputs and outputs that were derived from priori anatomical knowledge. We found group differences between normal control and mTLE groups in RSFC for nuclei seeds located in various subdivisions of thalamus. The RSFCs in some of those nuclei were strongly correlated with seizure frequency. Conclusions: Mediodorsal thalamic nuclei may play important roles in seizure activity or in the regulation of neuronal activity in the limbic system. The RSFC of motor- and sensory-relay nuclei may help elucidate sensory-motor deficits associated with chronic seizure activity. RSFC of the pulvinar nuclei of the thalamus could also be a key reflection of symptom-related functional deficits in mTLE.http://www.sciencedirect.com/science/article/pii/S221315821930021X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hang Joon Jo Daniel L. Kenny-Jung Irena Balzekas Eduardo E. Benarroch David T. Jones Benjamin H. Brinkmann S. Matt Stead Jamie J. Van Gompel Kirk M. Welker Gregory A. Worrell |
spellingShingle |
Hang Joon Jo Daniel L. Kenny-Jung Irena Balzekas Eduardo E. Benarroch David T. Jones Benjamin H. Brinkmann S. Matt Stead Jamie J. Van Gompel Kirk M. Welker Gregory A. Worrell Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy NeuroImage: Clinical |
author_facet |
Hang Joon Jo Daniel L. Kenny-Jung Irena Balzekas Eduardo E. Benarroch David T. Jones Benjamin H. Brinkmann S. Matt Stead Jamie J. Van Gompel Kirk M. Welker Gregory A. Worrell |
author_sort |
Hang Joon Jo |
title |
Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy |
title_short |
Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy |
title_full |
Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy |
title_fullStr |
Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy |
title_full_unstemmed |
Nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy |
title_sort |
nuclei-specific thalamic connectivity predicts seizure frequency in drug-resistant medial temporal lobe epilepsy |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2019-01-01 |
description |
Background and objectives: We assessed correlations between the resting state functional connectivity (RSFC) of different thalamic nuclei and seizure frequency in patients with drug-resistant medial temporal lobe epilepsy (mTLE). Methods: Seventeen patients with mTLE and 17 sex-/age-/handedness-matched controls participated. A seed-based correlation method for the resting-state FMRI data was implemented to get RSFC maps of 70 thalamic nuclei seed masks. Group statistics for individual RSFC for subjects and seed masks were performed to obtain within-group characteristics and between-group differences with age covariates. A linear regression was applied to test whether seizure frequency correlated with thalamic nuclear RSFC with the whole brain in mTLE patients. Results: RSFC of thalamic nuclei showed spatially distinguishable connectivity patterns that reflected principal inputs and outputs that were derived from priori anatomical knowledge. We found group differences between normal control and mTLE groups in RSFC for nuclei seeds located in various subdivisions of thalamus. The RSFCs in some of those nuclei were strongly correlated with seizure frequency. Conclusions: Mediodorsal thalamic nuclei may play important roles in seizure activity or in the regulation of neuronal activity in the limbic system. The RSFC of motor- and sensory-relay nuclei may help elucidate sensory-motor deficits associated with chronic seizure activity. RSFC of the pulvinar nuclei of the thalamus could also be a key reflection of symptom-related functional deficits in mTLE. |
url |
http://www.sciencedirect.com/science/article/pii/S221315821930021X |
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