Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice
Background and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1 generation male NMRI mice. Materials and Methods: Twenty female pregnant mice were randomly divided into stress and cont...
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Kurdistan University of Medical Sciences
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doaj-e48af9d0a52e4e3aac0dc8595ad4da512020-11-25T02:26:00Zfas Kurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان1560-652X2345-40402018-08-012337384Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male miceAliabadi N0 Hedayat Sahraei H1Bahari Z2Meftahi G.H3MSc of biology, Department of Biology, Azad Islamic University, North Branch, Tehran, IranProfessor, Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranAssistant Professor, Department of Physiology and Medical Physic, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IranAssistant Professor, Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranBackground and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1 generation male NMRI mice. Materials and Methods: Twenty female pregnant mice were randomly divided into stress and control groups. The stress group received stress using a restraint cylinder (6 cm ID, 20 cm L) 60 min/day from the 1st to the 15th day of pregnancy. The control group did not receive stress. The male F1 offspring was nursed by their mothers (n=10/group) until reaching weights between 20 and 25 g. Then they were tested for spatial memory using Barnes maze and anxiety-like behavior by the elevated plus-maze. Also, brain BDNF level was measured by means of an ELISA reader. Results: Barnes maze test results showed that the time and distance to reach the target hole were significantly (p<0.001) increased in the stress group. Also, the number of errors and anxiety-like behavior in the stress group were significantly (p<0.001) increased compared to those in the control group (p<0.001). BDNF level in the brain was significantly (p<0.05) higher in the control group. Conclusion: The present study indicated that prenatal stress can lead to decreased level of BDNF in the brain of the offspring which may result in spatial memory disorder and anxietylike behavior.http://sjku.muk.ac.ir/article-1-4269-en.pdfrestraint stressbarnes mazespatial memoryanxiety-like behaviorbdnf |
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language |
fas |
format |
Article |
sources |
DOAJ |
author |
Aliabadi N Hedayat Sahraei H Bahari Z Meftahi G.H |
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Aliabadi N Hedayat Sahraei H Bahari Z Meftahi G.H Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice مجله علمی دانشگاه علوم پزشکی کردستان restraint stress barnes maze spatial memory anxiety-like behavior bdnf |
author_facet |
Aliabadi N Hedayat Sahraei H Bahari Z Meftahi G.H |
author_sort |
Aliabadi N |
title |
Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice |
title_short |
Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice |
title_full |
Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice |
title_fullStr |
Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice |
title_full_unstemmed |
Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice |
title_sort |
effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain bdnf concentration in the f1 generation male mice |
publisher |
Kurdistan University of Medical Sciences |
series |
مجله علمی دانشگاه علوم پزشکی کردستان |
issn |
1560-652X 2345-4040 |
publishDate |
2018-08-01 |
description |
Background and Aim: In this study, we investigated the effect of immobilization stress
during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1
generation male NMRI mice.
Materials and Methods: Twenty female pregnant mice were randomly divided into stress
and control groups. The stress group received stress using a restraint cylinder (6 cm ID, 20 cm
L) 60 min/day from the 1st to the 15th day of pregnancy. The control group did not receive
stress. The male F1 offspring was nursed by their mothers (n=10/group) until reaching weights
between 20 and 25 g. Then they were tested for spatial memory using Barnes maze and
anxiety-like behavior by the elevated plus-maze. Also, brain BDNF level was measured by
means of an ELISA reader.
Results: Barnes maze test results showed that the time and distance to reach the target hole
were significantly (p<0.001) increased in the stress group. Also, the number of errors and
anxiety-like behavior in the stress group were significantly (p<0.001) increased compared to
those in the control group (p<0.001). BDNF level in the brain was significantly (p<0.05)
higher in the control group.
Conclusion: The present study indicated that prenatal stress can lead to decreased level of
BDNF in the brain of the offspring which may result in spatial memory disorder and anxietylike behavior. |
topic |
restraint stress barnes maze spatial memory anxiety-like behavior bdnf |
url |
http://sjku.muk.ac.ir/article-1-4269-en.pdf |
work_keys_str_mv |
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