Effects of interaction CdZn on serum-PSA level and prostate histology in rats
Objective: To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats. Methods: The study included 40 adult male rats, divided into four groups: Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4ZnCl2) and Gr...
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Wolters Kluwer Medknow Publications
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doaj-e49e99ef38824fb5bc6436b8b6c4fe4b2020-11-24T22:02:38ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Biomedicine2221-16912017-03-017324524810.1016/j.apjtb.2016.12.012Effects of interaction CdZn on serum-PSA level and prostate histology in ratsAbdelkrim Berroukche0Mohamed Terras1Abdelrahmane Labani2Hafsa Dellaoui3Wassila Lansari4Laboratory of Water Resources and Environment, Biology Department, Faculty of Sciences, Tahar-Moulay University, Saida, 20000, AlgeriaLaboratory of Water Resources and Environment, Biology Department, Faculty of Sciences, Tahar-Moulay University, Saida, 20000, AlgeriaLaboratory of Water Resources and Environment, Biology Department, Faculty of Sciences, Tahar-Moulay University, Saida, 20000, AlgeriaLaboratory of Bio-Toxicology, Pharmacognosy and Biological Recycling Plant, Biology Department, Faculty of Sciences, Tahar-Moulay University, Saida, 20000, AlgeriaLaboratory of Bio-Toxicology, Pharmacognosy and Biological Recycling Plant, Biology Department, Faculty of Sciences, Tahar-Moulay University, Saida, 20000, AlgeriaObjective: To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats. Methods: The study included 40 adult male rats, divided into four groups: Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4ZnCl2) and Group 4 (control). Animals were treated with CdSO4 and ZnCl2 at the same dose (15 mg/L) during 30 days. Results: It was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/mL] in animals treated with CdSO4. CdSO4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl2 were not recorded in this study. Conclusions: Protective role of zinc was exhibited against toxic effects of cadmium in prostate gland.http://www.sciencedirect.com/science/article/pii/S2221169116311418CadmiumZincPSAHyperplasia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abdelkrim Berroukche Mohamed Terras Abdelrahmane Labani Hafsa Dellaoui Wassila Lansari |
spellingShingle |
Abdelkrim Berroukche Mohamed Terras Abdelrahmane Labani Hafsa Dellaoui Wassila Lansari Effects of interaction CdZn on serum-PSA level and prostate histology in rats Asian Pacific Journal of Tropical Biomedicine Cadmium Zinc PSA Hyperplasia |
author_facet |
Abdelkrim Berroukche Mohamed Terras Abdelrahmane Labani Hafsa Dellaoui Wassila Lansari |
author_sort |
Abdelkrim Berroukche |
title |
Effects of interaction CdZn on serum-PSA level and prostate histology in rats |
title_short |
Effects of interaction CdZn on serum-PSA level and prostate histology in rats |
title_full |
Effects of interaction CdZn on serum-PSA level and prostate histology in rats |
title_fullStr |
Effects of interaction CdZn on serum-PSA level and prostate histology in rats |
title_full_unstemmed |
Effects of interaction CdZn on serum-PSA level and prostate histology in rats |
title_sort |
effects of interaction cdzn on serum-psa level and prostate histology in rats |
publisher |
Wolters Kluwer Medknow Publications |
series |
Asian Pacific Journal of Tropical Biomedicine |
issn |
2221-1691 |
publishDate |
2017-03-01 |
description |
Objective: To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats.
Methods: The study included 40 adult male rats, divided into four groups: Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4ZnCl2) and Group 4 (control). Animals were treated with CdSO4 and ZnCl2 at the same dose (15 mg/L) during 30 days.
Results: It was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/mL] in animals treated with CdSO4. CdSO4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl2 were not recorded in this study.
Conclusions: Protective role of zinc was exhibited against toxic effects of cadmium in prostate gland. |
topic |
Cadmium Zinc PSA Hyperplasia |
url |
http://www.sciencedirect.com/science/article/pii/S2221169116311418 |
work_keys_str_mv |
AT abdelkrimberroukche effectsofinteractioncdznonserumpsalevelandprostatehistologyinrats AT mohamedterras effectsofinteractioncdznonserumpsalevelandprostatehistologyinrats AT abdelrahmanelabani effectsofinteractioncdznonserumpsalevelandprostatehistologyinrats AT hafsadellaoui effectsofinteractioncdznonserumpsalevelandprostatehistologyinrats AT wassilalansari effectsofinteractioncdznonserumpsalevelandprostatehistologyinrats |
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1725834719515377664 |