Effects of interaction CdZn on serum-PSA level and prostate histology in rats

• Main Authors: Abdelkrim Berroukche, Mohamed Terras, Abdelrahmane Labani, Hafsa Dellaoui, Wassila Lansari
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2017-03-01
• Series: Asian Pacific Journal of Tropical Biomedicine
• Subjects: Cadmium; Zinc; PSA; Hyperplasia
• Online Access: http://www.sciencedirect.com/science/article/pii/S2221169116311418

Objective: To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats. Methods: The study included 40 adult male rats, divided into four groups: Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4ZnCl2) and Group 4 (control). Animals were treated with CdSO4 and ZnCl2 at the same dose (15 mg/L) during 30 days. Results: It was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/mL] in animals treated with CdSO4. CdSO4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl2 were not recorded in this study. Conclusions: Protective role of zinc was exhibited against toxic effects of cadmium in prostate gland.