LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling

LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling

Abstract Background In this research, we aimed to investigate the biological functions of LIM domain only 3 (LMO3) in hepatocellular carcinoma (HCC) and uncover the underlying molecular mechanism in it. Methods HCC tissue microarray (n = 180) was used to analyze the correlation between LMO3 expressi...

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Bibliographic Details
Main Authors: Yang Cheng, Tianlu Hou, Jian Ping, Tianyang Chen, Baobing Yin
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
LMO3
Hepatocellular carcinoma
Invasion
Metastasis
Hippo signaling
Online Access:http://link.springer.com/article/10.1186/s13046-018-0903-3

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