Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system

Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system

The dopamine (DA) transporter (DAT) is a plasma membrane glycoprotein expressed in dopaminergic (DA-) cells that takes back DA into presynaptic neurons after its release. DAT dysfunction has been involved in different neuro-psychiatric disorders including Parkinson's disease (PD). On the other...

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Bibliographic Details
Main Authors: Pedro Barroso-Chinea, Ignacio Cruz-Muros, Domingo Afonso-Oramas, Javier Castro-Hernández, Josmar Salas-Hernández, Abdelwahed Chtarto, Diego Luis-Ravelo, Marie Humbert-Claude, Liliane Tenenbaum, Tomás González-Hernández
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Neurobiology of Disease
Subjects:
Dopamine transporter
Tyrosine hydroxylase
GDNF
Inducible adeno-associated viral vectors
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300043

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http://www.sciencedirect.com/science/article/pii/S0969996116300043

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