Widespread cryptic variation in genetic architecture between the sexes
Abstract The majority of the genome is shared between the sexes, and it is expected that the genetic architecture of most traits is shared as well. This common architecture has been viewed as a major source of constraint on the evolution of sexual dimorphism (SD). SD is nonetheless common in nature,...
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Online Access: | https://doi.org/10.1002/evl3.245 |
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doaj-e4b3d93249564d3e993770909a778b462021-08-02T14:22:29ZengWileyEvolution Letters2056-37442021-08-015435936910.1002/evl3.245Widespread cryptic variation in genetic architecture between the sexesWouter van derBijl0Judith E. Mank1Department of Zoology University of British Columbia Vancouver BC V6T 1Z4 CanadaDepartment of Zoology University of British Columbia Vancouver BC V6T 1Z4 CanadaAbstract The majority of the genome is shared between the sexes, and it is expected that the genetic architecture of most traits is shared as well. This common architecture has been viewed as a major source of constraint on the evolution of sexual dimorphism (SD). SD is nonetheless common in nature, leading to assumptions that it results from differential regulation of shared genetic architecture. Here, we study the effect of thousands of gene knockout mutations on 202 mouse phenotypes to explore how regulatory variation affects SD. We show that many traits are dimorphic to some extent, and that a surprising proportion of knockouts have sex‐specific phenotypic effects. Many traits, regardless whether they are monomorphic or dimorphic, harbor cryptic differences in genetic architecture between the sexes, resulting in sexually discordant phenotypic effects from sexually concordant regulatory changes. This provides an alternative route to dimorphism through sex‐specific genetic architecture, rather than differential regulation of shared architecture.https://doi.org/10.1002/evl3.245Between‐sex genetic correlationgenetic architectureknockoutrFMsexual dimorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wouter van derBijl Judith E. Mank |
spellingShingle |
Wouter van derBijl Judith E. Mank Widespread cryptic variation in genetic architecture between the sexes Evolution Letters Between‐sex genetic correlation genetic architecture knockout rFM sexual dimorphism |
author_facet |
Wouter van derBijl Judith E. Mank |
author_sort |
Wouter van derBijl |
title |
Widespread cryptic variation in genetic architecture between the sexes |
title_short |
Widespread cryptic variation in genetic architecture between the sexes |
title_full |
Widespread cryptic variation in genetic architecture between the sexes |
title_fullStr |
Widespread cryptic variation in genetic architecture between the sexes |
title_full_unstemmed |
Widespread cryptic variation in genetic architecture between the sexes |
title_sort |
widespread cryptic variation in genetic architecture between the sexes |
publisher |
Wiley |
series |
Evolution Letters |
issn |
2056-3744 |
publishDate |
2021-08-01 |
description |
Abstract The majority of the genome is shared between the sexes, and it is expected that the genetic architecture of most traits is shared as well. This common architecture has been viewed as a major source of constraint on the evolution of sexual dimorphism (SD). SD is nonetheless common in nature, leading to assumptions that it results from differential regulation of shared genetic architecture. Here, we study the effect of thousands of gene knockout mutations on 202 mouse phenotypes to explore how regulatory variation affects SD. We show that many traits are dimorphic to some extent, and that a surprising proportion of knockouts have sex‐specific phenotypic effects. Many traits, regardless whether they are monomorphic or dimorphic, harbor cryptic differences in genetic architecture between the sexes, resulting in sexually discordant phenotypic effects from sexually concordant regulatory changes. This provides an alternative route to dimorphism through sex‐specific genetic architecture, rather than differential regulation of shared architecture. |
topic |
Between‐sex genetic correlation genetic architecture knockout rFM sexual dimorphism |
url |
https://doi.org/10.1002/evl3.245 |
work_keys_str_mv |
AT woutervanderbijl widespreadcrypticvariationingeneticarchitecturebetweenthesexes AT judithemank widespreadcrypticvariationingeneticarchitecturebetweenthesexes |
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