Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
Leukaemia cells resident in the bone marrow niche are often resistant to conventional therapies. In this study, the authors develop light-sensitive, polymeric, retinoic acid-containing nanoparticles that are able to modulate the differentiation of resistant leukaemia cells bothin vitro and in vivo.
Bibliographic Details
Main Authors: |
Carlos Boto,
Emanuel Quartin,
Yijun Cai,
Alberto Martín-Lorenzo,
María Begoña García Cenador,
Sandra Pinto,
Rajeev Gupta,
Tariq Enver,
Isidro Sánchez-García,
Dengli Hong,
Ricardo Pires das Neves,
Lino Ferreira |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-05-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms15204
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