Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

Leukaemia cells resident in the bone marrow niche are often resistant to conventional therapies. In this study, the authors develop light-sensitive, polymeric, retinoic acid-containing nanoparticles that are able to modulate the differentiation of resistant leukaemia cells bothin vitro and in vivo.

Bibliographic Details
Main Authors:	Carlos Boto, Emanuel Quartin, Yijun Cai, Alberto Martín-Lorenzo, María Begoña García Cenador, Sandra Pinto, Rajeev Gupta, Tariq Enver, Isidro Sánchez-García, Dengli Hong, Ricardo Pires das Neves, Lino Ferreira
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15204

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spelling	doaj-e4bdd43ae19445c3acce605c66e63d912021-05-11T07:31:10ZengNature Publishing GroupNature Communications2041-17232017-05-018111310.1038/ncomms15204Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activationCarlos Boto0Emanuel Quartin1Yijun Cai2Alberto Martín-Lorenzo3María Begoña García Cenador4Sandra Pinto5Rajeev Gupta6Tariq Enver7Isidro Sánchez-García8Dengli Hong9Ricardo Pires das Neves10Lino Ferreira11CNC-Center for Neurosciences and Cell Biology, University of CoimbraCNC-Center for Neurosciences and Cell Biology, University of CoimbraDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of MedicineExperimental Therapeutics and Translational Oncology Program, Instituto de Biologia Molecular y Celular del Cancer (IBMCC), CSIC/University of SalamancaInstitute of Biomedical Research of Salamanca (IBSAL)CNC-Center for Neurosciences and Cell Biology, University of CoimbraUCL Cancer Institute, University College LondonUCL Cancer Institute, University College LondonExperimental Therapeutics and Translational Oncology Program, Instituto de Biologia Molecular y Celular del Cancer (IBMCC), CSIC/University of SalamancaDepartment of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of MedicineCNC-Center for Neurosciences and Cell Biology, University of CoimbraCNC-Center for Neurosciences and Cell Biology, University of CoimbraLeukaemia cells resident in the bone marrow niche are often resistant to conventional therapies. In this study, the authors develop light-sensitive, polymeric, retinoic acid-containing nanoparticles that are able to modulate the differentiation of resistant leukaemia cells bothin vitro and in vivo.https://doi.org/10.1038/ncomms15204
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Carlos Boto Emanuel Quartin Yijun Cai Alberto Martín-Lorenzo María Begoña García Cenador Sandra Pinto Rajeev Gupta Tariq Enver Isidro Sánchez-García Dengli Hong Ricardo Pires das Neves Lino Ferreira
spellingShingle	Carlos Boto Emanuel Quartin Yijun Cai Alberto Martín-Lorenzo María Begoña García Cenador Sandra Pinto Rajeev Gupta Tariq Enver Isidro Sánchez-García Dengli Hong Ricardo Pires das Neves Lino Ferreira Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation Nature Communications
author_facet	Carlos Boto Emanuel Quartin Yijun Cai Alberto Martín-Lorenzo María Begoña García Cenador Sandra Pinto Rajeev Gupta Tariq Enver Isidro Sánchez-García Dengli Hong Ricardo Pires das Neves Lino Ferreira
author_sort	Carlos Boto
title	Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
title_short	Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
title_full	Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
title_fullStr	Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
title_full_unstemmed	Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
title_sort	prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-05-01
description	Leukaemia cells resident in the bone marrow niche are often resistant to conventional therapies. In this study, the authors develop light-sensitive, polymeric, retinoic acid-containing nanoparticles that are able to modulate the differentiation of resistant leukaemia cells bothin vitro and in vivo.
url	https://doi.org/10.1038/ncomms15204
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Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

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