Modern concepts of the mycosis fungoides pathogenesis

• Main Authors: A. A. Vorontsova, A. E. Karamova, L. F. Znamenskaya
• Format: Article
• Language: Russian
• Published: ABV-press 2018-10-01
• Series: Onkogematologiâ
• Subjects: cutaneous t-cell lymphoma; mycosis fungoides; mechanisms of development; pathogenesis; cytokines; interleukin; t-lymphocytes; signaling proteins; micro-rna
• Online Access: https://oncohematology.abvpress.ru/ongm/article/view/305

Mycosis fungoides – the most common form of cutaneous T-cell lymphoma. The pathogenesis of this disease is complex and remains unclear. The article contains a review of the literature devoted to the main mechanisms of T-lymphocytes malignant proliferation, known to date. Data on dysregulation of immune, genetic and epigenetic mechanisms, as well as the role of microenvironment cells in the proliferation of T lymphocytes, are given. Immunophenotypic characteristics and cellular composition of the infiltrate in patients with mycosis fungoides, are described depending on the stage of the disease. Prospective directions in studying molecular-biological predictors of malignant lymphoproliferative diseases development are highlighted.