Neuropilin-1 as therapeutic target for malignant melanoma
Neuropilin-1 (NRP-1) is a transmembrane glycoprotein that acts as a co-receptor for various members of the VEGF family. Its ability to bind or modulate the activity of a number of other extracellular ligands, such as class 3 semaphorins, TGF-β, HGF, FGF and PDGF, has suggested the involvement of NRP...
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doaj-e4d4c44f71a9459bad228f85ecad6aaf2020-11-24T21:13:31ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-06-01510.3389/fonc.2015.00125149115Neuropilin-1 as therapeutic target for malignant melanomaGrazia eGraziani0Pedro M Lacal1University of Rome Tor VergataIstituto Dermopatico dell'Immacolata-IRCCSNeuropilin-1 (NRP-1) is a transmembrane glycoprotein that acts as a co-receptor for various members of the VEGF family. Its ability to bind or modulate the activity of a number of other extracellular ligands, such as class 3 semaphorins, TGF-β, HGF, FGF and PDGF, has suggested the involvement of NRP-1 in a variety of physiological and pathological processes. Actually, this co-receptor has been implicated in axon guidance, angiogenesis and immune responses. NRP-1 is also expressed in a variety of cancers (prostate, lung, pancreatic or colon carcinoma, melanoma, astrocytoma, glioblastoma and neuroblastoma), suggesting a critical role in tumor progression. Moreover, a growing amount of evidence indicates that NRP-1 might display important functions independently of other VEGF receptors. In particular, in the absence of VEGFR-1/2, NRP-1 promotes melanoma invasiveness, through the activation of selected integrins, by stimulating VEGF-A and metalloproteinases secretion and modulating specific signal transduction pathways. This review is focused on the role of NRP-1 in melanoma aggressiveness and on the evidence supporting its use as target of therapies for metastatic melanoma.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00125/fullCell-Penetrating PeptidesMelanomaNeuropilin-1PeptidomimeticsmetastasisAngiogenesis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Grazia eGraziani Pedro M Lacal |
spellingShingle |
Grazia eGraziani Pedro M Lacal Neuropilin-1 as therapeutic target for malignant melanoma Frontiers in Oncology Cell-Penetrating Peptides Melanoma Neuropilin-1 Peptidomimetics metastasis Angiogenesis |
author_facet |
Grazia eGraziani Pedro M Lacal |
author_sort |
Grazia eGraziani |
title |
Neuropilin-1 as therapeutic target for malignant melanoma |
title_short |
Neuropilin-1 as therapeutic target for malignant melanoma |
title_full |
Neuropilin-1 as therapeutic target for malignant melanoma |
title_fullStr |
Neuropilin-1 as therapeutic target for malignant melanoma |
title_full_unstemmed |
Neuropilin-1 as therapeutic target for malignant melanoma |
title_sort |
neuropilin-1 as therapeutic target for malignant melanoma |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2015-06-01 |
description |
Neuropilin-1 (NRP-1) is a transmembrane glycoprotein that acts as a co-receptor for various members of the VEGF family. Its ability to bind or modulate the activity of a number of other extracellular ligands, such as class 3 semaphorins, TGF-β, HGF, FGF and PDGF, has suggested the involvement of NRP-1 in a variety of physiological and pathological processes. Actually, this co-receptor has been implicated in axon guidance, angiogenesis and immune responses. NRP-1 is also expressed in a variety of cancers (prostate, lung, pancreatic or colon carcinoma, melanoma, astrocytoma, glioblastoma and neuroblastoma), suggesting a critical role in tumor progression. Moreover, a growing amount of evidence indicates that NRP-1 might display important functions independently of other VEGF receptors. In particular, in the absence of VEGFR-1/2, NRP-1 promotes melanoma invasiveness, through the activation of selected integrins, by stimulating VEGF-A and metalloproteinases secretion and modulating specific signal transduction pathways. This review is focused on the role of NRP-1 in melanoma aggressiveness and on the evidence supporting its use as target of therapies for metastatic melanoma. |
topic |
Cell-Penetrating Peptides Melanoma Neuropilin-1 Peptidomimetics metastasis Angiogenesis |
url |
http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00125/full |
work_keys_str_mv |
AT graziaegraziani neuropilin1astherapeutictargetformalignantmelanoma AT pedromlacal neuropilin1astherapeutictargetformalignantmelanoma |
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