Studying Brugada Syndrome With an SCN1B Variants in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Studying Brugada Syndrome With an SCN1B Variants in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

BackgroundAmong rare channelopathies BrS patients are at high risk of sudden cardiac death (SCD). SCN5A mutations are found in a quarter of patients. Other rare gene mutations including SCN1B have been implicated to BrS. Studying the human cellular phenotype of BrS associated with rare gene mutation...

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Bibliographic Details
Main Authors: Ibrahim El-Battrawy, Jonas Müller, Zhihan Zhao, Lukas Cyganek, Rujia Zhong, Feng Zhang, Mandy Kleinsorge, Huan Lan, Xin Li, Qiang Xu, Mengying Huang, Zhenxing Liao, Alexander Moscu-Gregor, Sebastian Albers, Hendrik Dinkel, Siegfried Lang, Sebastian Diecke, Wolfram-Hubertus Zimmermann, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiaobo Zhou, Ibrahim Akin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Brugada
sudden cardiac death
channelopathy
genetic
sodium channel
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00261/full

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