Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model

The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstr...

Full description

Bibliographic Details
Main Authors:	Vadim Grigura, Megan Barbier, Anna P. Zarov, Charles K. Kaufman
Format:	Article
Language:	English
Published:	The Company of Biologists 2018-01-01
Series:	Biology Open
Subjects:	Melanoma Cancer models Metabolism Obesity Caloric restriction
Online Access:	http://bio.biologists.org/content/7/1/bio030726

id	doaj-e4e3459e07074789b0f18a4a21e0f6fe
record_format	Article
spelling	doaj-e4e3459e07074789b0f18a4a21e0f6fe2021-06-02T12:50:51ZengThe Company of BiologistsBiology Open2046-63902018-01-017110.1242/bio.030726030726Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma modelVadim Grigura0Megan Barbier1Anna P. Zarov2Charles K. Kaufman3 Division of Medical Oncology, Department of Medicine and Department of Developmental Biology, Washington University in Saint Louis, 4518 McKinley Ave., CB 8069, St. Louis, MO 63110, USA Division of Medical Oncology, Department of Medicine and Department of Developmental Biology, Washington University in Saint Louis, 4518 McKinley Ave., CB 8069, St. Louis, MO 63110, USA School of Arts and Sciences, Washington University in Saint Louis, 1 Brookings Drive, St. Louis, MO, 63130, USA Division of Medical Oncology, Department of Medicine and Department of Developmental Biology, Washington University in Saint Louis, 4518 McKinley Ave., CB 8069, St. Louis, MO 63110, USA The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstrate that increased feeding leads to more rapid melanoma onset. The ability to modulate overt tumor onset rates with this regimen indicates additional flexibility to ‘tune’ the system to more quickly generate tumors for study and to begin to address questions related to cancer metabolism using the zebrafish model.http://bio.biologists.org/content/7/1/bio030726MelanomaCancer modelsMetabolismObesityCaloric restriction
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Vadim Grigura Megan Barbier Anna P. Zarov Charles K. Kaufman
spellingShingle	Vadim Grigura Megan Barbier Anna P. Zarov Charles K. Kaufman Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model Biology Open Melanoma Cancer models Metabolism Obesity Caloric restriction
author_facet	Vadim Grigura Megan Barbier Anna P. Zarov Charles K. Kaufman
author_sort	Vadim Grigura
title	Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
title_short	Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
title_full	Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
title_fullStr	Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
title_full_unstemmed	Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
title_sort	feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model
publisher	The Company of Biologists
series	Biology Open
issn	2046-6390
publishDate	2018-01-01
description	The manner in which zebrafish are fed may have important impacts on the behavior of disease models. We examined the effect of different feeding regimens on the rate of overt melanoma tumor onset in a p53/BRAF-dependent model, a commonly used read-out in this and many other cancer models. We demonstrate that increased feeding leads to more rapid melanoma onset. The ability to modulate overt tumor onset rates with this regimen indicates additional flexibility to ‘tune’ the system to more quickly generate tumors for study and to begin to address questions related to cancer metabolism using the zebrafish model.
topic	Melanoma Cancer models Metabolism Obesity Caloric restriction
url	http://bio.biologists.org/content/7/1/bio030726
work_keys_str_mv	AT vadimgrigura feedingamountsignificantlyaltersoverttumoronsetrateinazebrafishmelanomamodel AT meganbarbier feedingamountsignificantlyaltersoverttumoronsetrateinazebrafishmelanomamodel AT annapzarov feedingamountsignificantlyaltersoverttumoronsetrateinazebrafishmelanomamodel AT charleskkaufman feedingamountsignificantlyaltersoverttumoronsetrateinazebrafishmelanomamodel
_version_	1721404355016392704

Feeding amount significantly alters overt tumor onset rate in a zebrafish melanoma model

Similar Items