Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease
Exercise has been shown to be beneficial for Parkinson's disease (PD). A major interest in our lab has been to investigate how exercise modulates basal ganglia function and modifies disease progression. Dopamine (DA) depletion leads to loss of dendritic spines within the caudate nucleus and put...
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doaj-e4e37f89fafa4270bcd08b6bf559a7102021-03-22T12:40:43ZengElsevierNeurobiology of Disease1095-953X2014-03-0163201209Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's diseaseWilliam A. Toy0Giselle M. Petzinger1Brian J. Leyshon2Garnik K. Akopian3John P. Walsh4Matilde V. Hoffman5Marta G. Vučković6Michael W. Jakowec7The George and MaryLou Boone Center for Parkinson's Disease Research, Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA; Corresponding author at: Department of Neurology, University of Southern California, 1333 San Pablo Street, MCA-241, Los Angeles, CA 90033, USA.The George and MaryLou Boone Center for Parkinson's Disease Research, Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA; The George and MaryLou Boone Center for Parkinson's Disease Research, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90033, USAThe George and MaryLou Boone Center for Parkinson's Disease Research, Department of Neurology, University of Southern California, Los Angeles, CA 90033, USAThe George and MaryLou Boone Center for Parkinson's Disease Research, Andrus Center for Gerontology, University of Southern California, Los Angeles, CA 90033, USAThe George and MaryLou Boone Center for Parkinson's Disease Research, Andrus Center for Gerontology, University of Southern California, Los Angeles, CA 90033, USAThe George and MaryLou Boone Center for Parkinson's Disease Research, Department of Neurology, University of Southern California, Los Angeles, CA 90033, USAThe George and MaryLou Boone Center for Parkinson's Disease Research, Department of Neurology, University of Southern California, Los Angeles, CA 90033, USAThe George and MaryLou Boone Center for Parkinson's Disease Research, Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA; The George and MaryLou Boone Center for Parkinson's Disease Research, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90033, USAExercise has been shown to be beneficial for Parkinson's disease (PD). A major interest in our lab has been to investigate how exercise modulates basal ganglia function and modifies disease progression. Dopamine (DA) depletion leads to loss of dendritic spines within the caudate nucleus and putamen (striatum) in PD and its animal models and contributes to motor impairments. Striatal medium spiny neurons (MSNs) can be delineated into two populations, the dopamine D1 receptor (DA-D1R)-containing MSNs of the direct pathway and dopamine D2 receptor (DA-D2R)-containing MSNs of the indirect pathway. There is evidence to suggest that the DA-D2R-indirect pathway MSNs may be preferentially affected after DA-depletion with a predominate loss of dendritic spine density when compared to MSNs of the DA-D1R-direct pathway in rodents; however, others have reported that both pathways may be affected in primates. The purpose of this study was to investigate the effects of intensive exercise on dendritic spine density and arborization in MSNs of these two pathways in the MPTP mouse model of PD. We found that MPTP led to a decrease in dendritic spine density in both DA-D1R- and DA-D2R-containing MSNs and 30 days of intensive treadmill exercise led to increased dendritic spine density and arborization in MSNs of both pathways. In addition, exercise increased the expression of synaptic proteins PSD-95 and synaptophysin. Taken together these findings support the potential effect of exercise in modifying synaptic connectivity within the DA-depleted striatum and in modifying disease progression in individuals with PD.http://www.sciencedirect.com/science/article/pii/S0969996113003306NeuroplasticityDopamineSynaptogenesisStriatumBasal gangliaParkinson's |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
William A. Toy Giselle M. Petzinger Brian J. Leyshon Garnik K. Akopian John P. Walsh Matilde V. Hoffman Marta G. Vučković Michael W. Jakowec |
spellingShingle |
William A. Toy Giselle M. Petzinger Brian J. Leyshon Garnik K. Akopian John P. Walsh Matilde V. Hoffman Marta G. Vučković Michael W. Jakowec Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease Neurobiology of Disease Neuroplasticity Dopamine Synaptogenesis Striatum Basal ganglia Parkinson's |
author_facet |
William A. Toy Giselle M. Petzinger Brian J. Leyshon Garnik K. Akopian John P. Walsh Matilde V. Hoffman Marta G. Vučković Michael W. Jakowec |
author_sort |
William A. Toy |
title |
Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease |
title_short |
Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease |
title_full |
Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease |
title_fullStr |
Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease |
title_full_unstemmed |
Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease |
title_sort |
treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model of parkinson's disease |
publisher |
Elsevier |
series |
Neurobiology of Disease |
issn |
1095-953X |
publishDate |
2014-03-01 |
description |
Exercise has been shown to be beneficial for Parkinson's disease (PD). A major interest in our lab has been to investigate how exercise modulates basal ganglia function and modifies disease progression. Dopamine (DA) depletion leads to loss of dendritic spines within the caudate nucleus and putamen (striatum) in PD and its animal models and contributes to motor impairments. Striatal medium spiny neurons (MSNs) can be delineated into two populations, the dopamine D1 receptor (DA-D1R)-containing MSNs of the direct pathway and dopamine D2 receptor (DA-D2R)-containing MSNs of the indirect pathway. There is evidence to suggest that the DA-D2R-indirect pathway MSNs may be preferentially affected after DA-depletion with a predominate loss of dendritic spine density when compared to MSNs of the DA-D1R-direct pathway in rodents; however, others have reported that both pathways may be affected in primates. The purpose of this study was to investigate the effects of intensive exercise on dendritic spine density and arborization in MSNs of these two pathways in the MPTP mouse model of PD. We found that MPTP led to a decrease in dendritic spine density in both DA-D1R- and DA-D2R-containing MSNs and 30 days of intensive treadmill exercise led to increased dendritic spine density and arborization in MSNs of both pathways. In addition, exercise increased the expression of synaptic proteins PSD-95 and synaptophysin. Taken together these findings support the potential effect of exercise in modifying synaptic connectivity within the DA-depleted striatum and in modifying disease progression in individuals with PD. |
topic |
Neuroplasticity Dopamine Synaptogenesis Striatum Basal ganglia Parkinson's |
url |
http://www.sciencedirect.com/science/article/pii/S0969996113003306 |
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