Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

Exercise has been shown to be beneficial for Parkinson's disease (PD). A major interest in our lab has been to investigate how exercise modulates basal ganglia function and modifies disease progression. Dopamine (DA) depletion leads to loss of dendritic spines within the caudate nucleus and put...

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Bibliographic Details
Main Authors: William A. Toy, Giselle M. Petzinger, Brian J. Leyshon, Garnik K. Akopian, John P. Walsh, Matilde V. Hoffman, Marta G. Vučković, Michael W. Jakowec
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Neurobiology of Disease
Subjects:
Neuroplasticity
Dopamine
Synaptogenesis
Striatum
Basal ganglia
Parkinson's
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113003306

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http://www.sciencedirect.com/science/article/pii/S0969996113003306

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