Neuroprotective Activity of Water Soluble Extract from Chorispora bungeana against Focal Cerebral Ischemic/Reperfusion Injury in Mice
The purpose of the present study was to clarify whether the water extract of Chorispora bungeana was an antioxidant agent against cerebral ischemia/reperfusion (I/R). Our results showed that water extract of Chorispora bungeana treatment significantly reduced neurological deficit scores, infarct siz...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2014-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/373872 |
| Summary: | The purpose of the present study was to clarify whether the water extract of Chorispora bungeana was an antioxidant agent against cerebral ischemia/reperfusion (I/R). Our results showed that water extract of Chorispora bungeana treatment significantly reduced neurological deficit scores, infarct size, MDA and carbonyl contents, and GSH/GSSG ratio compared with the model control group. After being treated by Chorispora bungeana, SOD, CAT, and GSH-Px activities remarkably increased. Chorispora bungeana treatment also improved 8-OHdG expression and cell apoptosis. Our findings indicated that the water extract of Chorispora bungeana possesses neuroprotective effect which is most likely achieved by antioxidant and antiapoptotic activities. |
|---|---|
| ISSN: | 2090-9063 2090-9071 |