Psychotic symptoms due to topiramate
Topiramate is an antiepileptic drug prescribed in the treatment of numerous psychiatric disorders and in epilepsy. Topiramate exerts its antiepileptic effect through different mechanisms, such as by the blockage of sodium channels, increasing GABAergic neurotransmission, antagonizing excitatory am...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Medical Communications Sp. z o.o.
2015-04-01
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| Series: | Psychiatria i Psychologia Kliniczna |
| Subjects: | |
| Online Access: | http://www.psychiatria.com.pl/index.php/wydawnictwa/2015-vol-15-no-1/psychotic-symptoms-due-to-topiramate?aid=508 |
| Summary: | Topiramate is an antiepileptic drug prescribed in the treatment of numerous psychiatric disorders and in epilepsy.
Topiramate exerts its antiepileptic effect through different mechanisms, such as by the blockage of sodium channels,
increasing GABAergic neurotransmission, antagonizing excitatory amino acid receptors (glutamate) or blocking
calcium channels. Its prescription in psychiatric diseases has increased in recent years and psychotic symptom
development due to the usage of topiramate has been observed in some studies. Therefore, it is essential to evaluate
the patient for psychotic symptoms while using topiramate. This article presents a case of a 37-year-old woman
who developed depression, anxiety and auditory hallucinations during the treatment with 150 mg of topiramate.
After stopping topiramate, 5 mg of olanzapine bid was started and the symptoms gradually decreased and finally
disappeared. |
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| ISSN: | 1644-6313 2451-0645 |