The effect of mundu fruit Garcinia dulcis Roxb Kurz methanol extract on lyphoprotein profile and trygliseride white rat Rattus norvegicus L
Garcinia dulcis (Roxb.) Kurz) (Guttiferae) is a tropical fruit tree native to Indonesia and its known as an Asian medicinal plant used in folk medicines. In ethno pharmacology, Garcinia dulcis has been used in traditional medicine, such as anti-inflammatory, anti-tumor, anti-malaria and anti-bacteri...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Indonesian Biological Society
2015-02-01
|
Series: | Journal of Biological Researches |
Subjects: | |
Online Access: | http://berkalahayati.org/journal/8053af29 |
id |
doaj-e4f13e831d8c4d309e0955a4ed4748b3 |
---|---|
record_format |
Article |
spelling |
doaj-e4f13e831d8c4d309e0955a4ed4748b32020-11-24T23:15:06ZengIndonesian Biological SocietyJournal of Biological Researches0852-68342337-389X2015-02-01192747710.23869/bphjbr.19.2.20146The effect of mundu fruit Garcinia dulcis Roxb Kurz methanol extract on lyphoprotein profile and trygliseride white rat Rattus norvegicus LArum Setiawan0Laila Hanum1Elvi Rusmiyanto Pancaning Wardoyo2Departement of Biology, Faculty of Mathematic and Natural Science, Sriwijaya University, Jl. Palembang-Prabumulih KM 32, Indralaya (OI) South Sumatera, Indonesia, 30662Departement of Biology, Faculty of Mathematic and Natural Science, Sriwijaya University, Jl. Palembang-Prabumulih KM 32, Indralaya (OI) South Sumatera, Indonesia, 30662Departement of Biology, Faculty of Mathematic and Natural Science, Tanjungpura University Jl. Prof. Hadari Nawawi, Pontianak, West Kalimantan, Indonesia 78124Garcinia dulcis (Roxb.) Kurz) (Guttiferae) is a tropical fruit tree native to Indonesia and its known as an Asian medicinal plant used in folk medicines. In ethno pharmacology, Garcinia dulcis has been used in traditional medicine, such as anti-inflammatory, anti-tumor, anti-malaria and anti-bacterial. The scientific studies of biological activity of Garcinia dulcis on lipide profile and trigliseride are relatively measly. Therefore, the objectives of this research were to know the effect of methanol extract of Garcinia dulcis fruit on total cholestrol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and triglyseride rat hyperlipidemic. These studies using Garcinia dulcis fruit from Banyuasin, South Sumatra. In this observation, 30 male rat from Laboratory and Research Institute for Integrated Testing, Gadjah Mada University, 2 months old were used and divided into five groups randomly. The first group was given high cholesterol and lipid diet, as a normal group. The second group was given high cholesterol, lipid diet and simvastatin 3,6 mg/kg bow/day dosage, as a simvastatin group. The third, fourth and fifth groups was given high cholesterol, lipid diet and methanol extract 1.8; 2.7 and 3.6 mg/kg bow/day dosage. Total cholestrol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and triglyseride contains using spectrophotometry method, were observed 1 and 30 days. The differences among groups were analyzed using Anova followed by LSD to locate the differences. LSD analysis showed that Garcinia dulcis methanol extract treatment doses of 3.6 mg/kg bw and simvastatin lowers total cholesterol levels highest in the amount of 32.17 mg/dL and 24.1 mg/dL, significantly different compared with the treatment dose of 1.8 mg/kg bw. Garcinia dulcis fruit methanol extract treatment doses of 3.6 mg/kg bw and simvastatin lowers triglyceride levels by 7.22 mg/dL and 24.58 mg/dL, significantly different compared with the treatment dose of 1.8 mg/kg bw and controls. Garcinia dulcis fruit extract dose of 3.6 mg/dL lower low density lipoprotein-cholesterol highest of 16.45 mg/dL. Garcinia dulcis fruit methanol extract dose of 3.6 mg/kg bw was also able to increase the levels of high density lipoprotein-cholesterol by 5.62 mg/dL. The results showed that the fruit of Garcinia dulcis contain compounds that have potential as agents antihiperlipidemia and presumably through inhibition of the enzyme HMG-CoA reductase. http://berkalahayati.org/journal/8053af29cholesterolGarcinia dulcistriglyseride |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Arum Setiawan Laila Hanum Elvi Rusmiyanto Pancaning Wardoyo |
spellingShingle |
Arum Setiawan Laila Hanum Elvi Rusmiyanto Pancaning Wardoyo The effect of mundu fruit Garcinia dulcis Roxb Kurz methanol extract on lyphoprotein profile and trygliseride white rat Rattus norvegicus L Journal of Biological Researches cholesterol Garcinia dulcis triglyseride |
author_facet |
Arum Setiawan Laila Hanum Elvi Rusmiyanto Pancaning Wardoyo |
author_sort |
Arum Setiawan |
title |
The effect of mundu fruit Garcinia dulcis Roxb Kurz methanol extract on lyphoprotein profile and trygliseride white rat Rattus norvegicus L |
title_short |
The effect of mundu fruit Garcinia dulcis Roxb Kurz methanol extract on lyphoprotein profile and trygliseride white rat Rattus norvegicus L |
title_full |
The effect of mundu fruit Garcinia dulcis Roxb Kurz methanol extract on lyphoprotein profile and trygliseride white rat Rattus norvegicus L |
title_fullStr |
The effect of mundu fruit Garcinia dulcis Roxb Kurz methanol extract on lyphoprotein profile and trygliseride white rat Rattus norvegicus L |
title_full_unstemmed |
The effect of mundu fruit Garcinia dulcis Roxb Kurz methanol extract on lyphoprotein profile and trygliseride white rat Rattus norvegicus L |
title_sort |
effect of mundu fruit garcinia dulcis roxb kurz methanol extract on lyphoprotein profile and trygliseride white rat rattus norvegicus l |
publisher |
Indonesian Biological Society |
series |
Journal of Biological Researches |
issn |
0852-6834 2337-389X |
publishDate |
2015-02-01 |
description |
Garcinia dulcis (Roxb.) Kurz) (Guttiferae) is a tropical fruit tree native to Indonesia and its known as an Asian medicinal plant used in folk medicines. In ethno pharmacology, Garcinia dulcis has been used in traditional medicine, such as anti-inflammatory, anti-tumor, anti-malaria and anti-bacterial. The scientific studies of biological activity of Garcinia dulcis on lipide profile and trigliseride are relatively measly. Therefore, the objectives of this research were to know the effect of methanol extract of Garcinia dulcis fruit on total cholestrol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and triglyseride rat hyperlipidemic. These studies using Garcinia dulcis fruit from Banyuasin, South Sumatra. In this observation, 30 male rat from Laboratory and Research Institute for Integrated Testing, Gadjah Mada University, 2 months old were used and divided into five groups randomly. The first group was given high cholesterol and lipid diet, as a normal group. The second group was given high cholesterol, lipid diet and simvastatin 3,6 mg/kg bow/day dosage, as a simvastatin group. The third, fourth and fifth groups was given high cholesterol, lipid diet and methanol extract 1.8; 2.7 and 3.6 mg/kg bow/day dosage. Total cholestrol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol and triglyseride contains using spectrophotometry method, were observed 1 and 30 days. The differences among groups were analyzed using Anova followed by LSD to locate the differences. LSD analysis showed that Garcinia dulcis methanol extract treatment doses of 3.6 mg/kg bw and simvastatin lowers total cholesterol levels highest in the amount of 32.17 mg/dL and 24.1 mg/dL, significantly different compared with the treatment dose of 1.8 mg/kg bw. Garcinia dulcis fruit methanol extract treatment doses of 3.6 mg/kg bw and simvastatin lowers triglyceride levels by 7.22 mg/dL and 24.58 mg/dL, significantly different compared with the treatment dose of 1.8 mg/kg bw and controls. Garcinia dulcis fruit extract dose of 3.6 mg/dL lower low density lipoprotein-cholesterol highest of 16.45 mg/dL. Garcinia dulcis fruit methanol extract dose of 3.6 mg/kg bw was also able to increase the levels of high density lipoprotein-cholesterol by 5.62 mg/dL. The results showed that the fruit of Garcinia dulcis contain compounds that have potential as agents antihiperlipidemia and presumably through inhibition of the enzyme HMG-CoA reductase.
|
topic |
cholesterol Garcinia dulcis triglyseride |
url |
http://berkalahayati.org/journal/8053af29 |
work_keys_str_mv |
AT arumsetiawan theeffectofmundufruitgarciniadulcisroxbkurzmethanolextractonlyphoproteinprofileandtrygliseridewhiteratrattusnorvegicusl AT lailahanum theeffectofmundufruitgarciniadulcisroxbkurzmethanolextractonlyphoproteinprofileandtrygliseridewhiteratrattusnorvegicusl AT elvirusmiyantopancaningwardoyo theeffectofmundufruitgarciniadulcisroxbkurzmethanolextractonlyphoproteinprofileandtrygliseridewhiteratrattusnorvegicusl AT arumsetiawan effectofmundufruitgarciniadulcisroxbkurzmethanolextractonlyphoproteinprofileandtrygliseridewhiteratrattusnorvegicusl AT lailahanum effectofmundufruitgarciniadulcisroxbkurzmethanolextractonlyphoproteinprofileandtrygliseridewhiteratrattusnorvegicusl AT elvirusmiyantopancaningwardoyo effectofmundufruitgarciniadulcisroxbkurzmethanolextractonlyphoproteinprofileandtrygliseridewhiteratrattusnorvegicusl |
_version_ |
1725592180017332224 |