The Influence of Low-Intensity Laser Therapy on Bone Healing
Objective: Low-intensity laser therapy (LILT) is defined to supply direct biostimulative light energy to the cells. While several studies have demonstrated that LILT has stimulating effects on bone cells and can accelerate the repair process of the bone, others reported delayed fracture healing or n...
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Tehran University of Medical Sciences
2012-01-01
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doaj-e4f72ee3199143d4a6540e63abcaa8572020-11-25T03:23:38ZengTehran University of Medical SciencesJournal of Dentistry of Tehran University of Medical Sciences 2008-21852012-01-0194338348The Influence of Low-Intensity Laser Therapy on Bone HealingT EbrahimiN MoslemiAR RoknM HeidariH NokhbatolfoghahaieR FekrazadObjective: Low-intensity laser therapy (LILT) is defined to supply direct biostimulative light energy to the cells. While several studies have demonstrated that LILT has stimulating effects on bone cells and can accelerate the repair process of the bone, others reported delayed fracture healing or no effects after LILT. The aim of this article was to review the studies evaluating the biomodulation effects of LILT on bone-derived stem cells.Materials and Methods: To access relevant articles, searching in three electronic databases including PubMed, Google Scholar and Science Direct was conducted until April 2012. The key words used were low-level laser, low-intensity laser, low-power laser therapy, stem cell, bone marrow stem cell, bone and osteoblast. The articles that met the eligibility criteria were included in this review of literature.Results: Twenty-five relevant articles (13 in vitro and 12 animal studies) were included. Eleven in vitro studies showed positive results with regard to acceleration of cell proliferation and differentiation. All animal studies showed improved bone healing in sites irradiated with low-intensity laser.Conclusion: Based on the results of the reviewed articles, low intensity laser therapy can accelerate bone healing in extraction sites, bone fracture defects and distraction osteogenesis, provided proper parameters were applied.http://jdt.tums.ac.ir/index.php/jdt/article/view/962/376Stem CellsOsteoblastLow-Level Laser TherapyLaser PhototherapyLaser BiostimulationStem CellsBone Marrow Cell |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
T Ebrahimi N Moslemi AR Rokn M Heidari H Nokhbatolfoghahaie R Fekrazad |
spellingShingle |
T Ebrahimi N Moslemi AR Rokn M Heidari H Nokhbatolfoghahaie R Fekrazad The Influence of Low-Intensity Laser Therapy on Bone Healing Journal of Dentistry of Tehran University of Medical Sciences Stem Cells Osteoblast Low-Level Laser Therapy Laser Phototherapy Laser Biostimulation Stem Cells Bone Marrow Cell |
author_facet |
T Ebrahimi N Moslemi AR Rokn M Heidari H Nokhbatolfoghahaie R Fekrazad |
author_sort |
T Ebrahimi |
title |
The Influence of Low-Intensity Laser Therapy on Bone Healing |
title_short |
The Influence of Low-Intensity Laser Therapy on Bone Healing |
title_full |
The Influence of Low-Intensity Laser Therapy on Bone Healing |
title_fullStr |
The Influence of Low-Intensity Laser Therapy on Bone Healing |
title_full_unstemmed |
The Influence of Low-Intensity Laser Therapy on Bone Healing |
title_sort |
influence of low-intensity laser therapy on bone healing |
publisher |
Tehran University of Medical Sciences |
series |
Journal of Dentistry of Tehran University of Medical Sciences |
issn |
2008-2185 |
publishDate |
2012-01-01 |
description |
Objective: Low-intensity laser therapy (LILT) is defined to supply direct biostimulative light energy to the cells. While several studies have demonstrated that LILT has stimulating effects on bone cells and can accelerate the repair process of the bone, others reported delayed fracture healing or no effects after LILT. The aim of this article was to review the studies evaluating the biomodulation effects of LILT on bone-derived stem cells.Materials and Methods: To access relevant articles, searching in three electronic databases including PubMed, Google Scholar and Science Direct was conducted until April 2012. The key words used were low-level laser, low-intensity laser, low-power laser therapy, stem cell, bone marrow stem cell, bone and osteoblast. The articles that met the eligibility criteria were included in this review of literature.Results: Twenty-five relevant articles (13 in vitro and 12 animal studies) were included. Eleven in vitro studies showed positive results with regard to acceleration of cell proliferation and differentiation. All animal studies showed improved bone healing in sites irradiated with low-intensity laser.Conclusion: Based on the results of the reviewed articles, low intensity laser therapy can accelerate bone healing in extraction sites, bone fracture defects and distraction osteogenesis, provided proper parameters were applied. |
topic |
Stem Cells Osteoblast Low-Level Laser Therapy Laser Phototherapy Laser Biostimulation Stem Cells Bone Marrow Cell |
url |
http://jdt.tums.ac.ir/index.php/jdt/article/view/962/376 |
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