Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex

Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex

In Alzheimer's disease (AD) brain, increased levels of cyclooxygenase-2 (COX-2), cell cycle markers, and p38 MAP kinase (MAPK) can be detected in neuronal cells. Besides mediating COX-2 expression, p38 MAPK is suggested to mediate cell cycle progression through phosphorylation of the retinoblas...

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Bibliographic Details
Main Authors: Jeroen J.M Hoozemans, Robert Veerhuis, Annemieke J.M Rozemuller, Thomas Arendt, Piet Eikelenboom
Format: Article
Language:English
Published: Elsevier 2004-04-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Amyloid β
Cell cycle
Cyclooxygenase-2
Neurofibrillary tangles
Neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002638

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