Significance of Atrial and Brain Natriuretic Peptide Measurements in Fetuses With Heart Failure
Fetal heart failure is mainly caused by congenital heart defect and arrhythmia. It is difficult to appropriately diagnose the severity of fetal heart failure simply by ultrasonography because the development of a fetal heart in fetoplacental circulation and how well the fetal myocardium can adapt to...
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2021-03-01
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doaj-e4f9fe6202764990a6d49635ad7534eb2021-03-18T05:39:01ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-03-011210.3389/fphys.2021.654356654356Significance of Atrial and Brain Natriuretic Peptide Measurements in Fetuses With Heart FailureTakekazu Miyoshi0Takekazu Miyoshi1Hiroshi Hosoda2Naoto Minamino3Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Suita, JapanClinical Research Center, National Center for Child Health and Development, Tokyo, JapanDepartment of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center, Suita, JapanOmics Research Center, National Cerebral and Cardiovascular Center, Suita, JapanFetal heart failure is mainly caused by congenital heart defect and arrhythmia. It is difficult to appropriately diagnose the severity of fetal heart failure simply by ultrasonography because the development of a fetal heart in fetoplacental circulation and how well the fetal myocardium can adapt to postnatal cardiopulmonary circulation are challenging to assess. In adult cardiology, natriuretic peptides (NPs) are the most useful biomarker of heart failure; however, studies investigating NP levels in the fetuses and amniotic fluid are quite limited. Furthermore, little is known about their production and metabolism. This review summarized the most relevant findings on NP levels in the umbilical cord blood and amniotic fluid. The findings can then extend their use as a diagnostic biomarker of heart failure in fetuses with congenital heart defect and/or arrhythmia.https://www.frontiersin.org/articles/10.3389/fphys.2021.654356/fullnatriuretic peptidefetal heart failurecongenital heart defectarrhythmiaplacentametabolism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Takekazu Miyoshi Takekazu Miyoshi Hiroshi Hosoda Naoto Minamino |
spellingShingle |
Takekazu Miyoshi Takekazu Miyoshi Hiroshi Hosoda Naoto Minamino Significance of Atrial and Brain Natriuretic Peptide Measurements in Fetuses With Heart Failure Frontiers in Physiology natriuretic peptide fetal heart failure congenital heart defect arrhythmia placenta metabolism |
author_facet |
Takekazu Miyoshi Takekazu Miyoshi Hiroshi Hosoda Naoto Minamino |
author_sort |
Takekazu Miyoshi |
title |
Significance of Atrial and Brain Natriuretic Peptide Measurements in Fetuses With Heart Failure |
title_short |
Significance of Atrial and Brain Natriuretic Peptide Measurements in Fetuses With Heart Failure |
title_full |
Significance of Atrial and Brain Natriuretic Peptide Measurements in Fetuses With Heart Failure |
title_fullStr |
Significance of Atrial and Brain Natriuretic Peptide Measurements in Fetuses With Heart Failure |
title_full_unstemmed |
Significance of Atrial and Brain Natriuretic Peptide Measurements in Fetuses With Heart Failure |
title_sort |
significance of atrial and brain natriuretic peptide measurements in fetuses with heart failure |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2021-03-01 |
description |
Fetal heart failure is mainly caused by congenital heart defect and arrhythmia. It is difficult to appropriately diagnose the severity of fetal heart failure simply by ultrasonography because the development of a fetal heart in fetoplacental circulation and how well the fetal myocardium can adapt to postnatal cardiopulmonary circulation are challenging to assess. In adult cardiology, natriuretic peptides (NPs) are the most useful biomarker of heart failure; however, studies investigating NP levels in the fetuses and amniotic fluid are quite limited. Furthermore, little is known about their production and metabolism. This review summarized the most relevant findings on NP levels in the umbilical cord blood and amniotic fluid. The findings can then extend their use as a diagnostic biomarker of heart failure in fetuses with congenital heart defect and/or arrhythmia. |
topic |
natriuretic peptide fetal heart failure congenital heart defect arrhythmia placenta metabolism |
url |
https://www.frontiersin.org/articles/10.3389/fphys.2021.654356/full |
work_keys_str_mv |
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