Congenital Hyperinsulinism: the Possibilities of Modern Diagnosis and Treatment
Congenital hyperinsulinism (CHI) — one of the main causes underlying the development of persistent hypoglycemic conditions in childhood. The article presents the experience of diagnosis and treatment in patients with CHI. We have examined 7 children diagnosed with СHI aged 1 month to 1.5 years. For...
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doaj-e4fad094c6fc46e0be9bc4319d0b9c272020-11-24T21:21:48ZengPublishing House ZaslavskyMìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272015-04-01113.6716617010.22141/2224-0721.3.67.2015.7529075290Congenital Hyperinsulinism: the Possibilities of Modern Diagnosis and TreatmentYe.V. Hloba0Ukrainian Scientific and Practical Centre for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of Ministry of Healthcare of Ukraine, KyivCongenital hyperinsulinism (CHI) — one of the main causes underlying the development of persistent hypoglycemic conditions in childhood. The article presents the experience of diagnosis and treatment in patients with CHI. We have examined 7 children diagnosed with СHI aged 1 month to 1.5 years. For diagnosing CHI, we have used routine clinical and laboratory investigations, as well as molecular genetic and instrumental diagnostics (18F-DOPA positron emission tomography). Molecular genetic testing confirmed the diagnosis of CHI in 6 children. All 7 children with CHI had various resistance to conservative treatment, had a different degree of psychomotor development and seizures. Of them, 6 children underwent surgery with achievement of normoglycemia. Genetic testing and 18F-DOPA positron emission tomography should be carried out in all children with hypoglycemia and increased or normal levels of C-peptide and insulin to clarify the type of CHI. Further development of genetic diagnostics is necessary to find new CHI genes. Surgical treatment may be a treatment of choice in children with CHI, particularly in its focal form.http://iej.zaslavsky.com.ua/article/view/75290congenital hyperinsulinismhypoglycemiachildrendiagnosis and treatment |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ye.V. Hloba |
spellingShingle |
Ye.V. Hloba Congenital Hyperinsulinism: the Possibilities of Modern Diagnosis and Treatment Mìžnarodnij Endokrinologìčnij Žurnal congenital hyperinsulinism hypoglycemia children diagnosis and treatment |
author_facet |
Ye.V. Hloba |
author_sort |
Ye.V. Hloba |
title |
Congenital Hyperinsulinism: the Possibilities of Modern Diagnosis and Treatment |
title_short |
Congenital Hyperinsulinism: the Possibilities of Modern Diagnosis and Treatment |
title_full |
Congenital Hyperinsulinism: the Possibilities of Modern Diagnosis and Treatment |
title_fullStr |
Congenital Hyperinsulinism: the Possibilities of Modern Diagnosis and Treatment |
title_full_unstemmed |
Congenital Hyperinsulinism: the Possibilities of Modern Diagnosis and Treatment |
title_sort |
congenital hyperinsulinism: the possibilities of modern diagnosis and treatment |
publisher |
Publishing House Zaslavsky |
series |
Mìžnarodnij Endokrinologìčnij Žurnal |
issn |
2224-0721 2307-1427 |
publishDate |
2015-04-01 |
description |
Congenital hyperinsulinism (CHI) — one of the main causes underlying the development of persistent hypoglycemic conditions in childhood. The article presents the experience of diagnosis and treatment in patients with CHI. We have examined 7 children diagnosed with СHI aged 1 month to 1.5 years. For diagnosing CHI, we have used routine clinical and laboratory investigations, as well as molecular genetic and instrumental diagnostics (18F-DOPA positron emission tomography). Molecular genetic testing confirmed the diagnosis of CHI in 6 children. All 7 children with CHI had various resistance to conservative treatment, had a different degree of psychomotor development and seizures. Of them, 6 children underwent surgery with achievement of normoglycemia. Genetic testing and 18F-DOPA positron emission tomography should be carried out in all children with hypoglycemia and increased or normal levels of C-peptide and insulin to clarify the type of CHI. Further development of genetic diagnostics is necessary to find new CHI genes. Surgical treatment may be a treatment of choice in children with CHI, particularly in its focal form. |
topic |
congenital hyperinsulinism hypoglycemia children diagnosis and treatment |
url |
http://iej.zaslavsky.com.ua/article/view/75290 |
work_keys_str_mv |
AT yevhloba congenitalhyperinsulinismthepossibilitiesofmoderndiagnosisandtreatment |
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