Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of Gait
Background: Freezing of gait (FOG) in Parkinson's disease (PD) is a devastating clinical phenomenon that has a detrimental impact on patients. It tends to be triggered more often during turning (complex) than during forwarding straight (simple) walking. The neural mechanism underlying this phen...
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Frontiers Media S.A.
2021-09-01
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Series: | Frontiers in Aging Neuroscience |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.731332/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hui-Chun Huang Hui-Chun Huang Hui-Chun Huang Hui-Chun Huang Hui-Chun Huang Chun-Ming Chen Chun-Ming Chen Ming-Kuei Lu Ming-Kuei Lu Ming-Kuei Lu Ming-Kuei Lu Bey-Ling Liu Chia-Ing Li Jui-Cheng Chen Jui-Cheng Chen Jui-Cheng Chen Jui-Cheng Chen Jui-Cheng Chen Guei-Jane Wang Guei-Jane Wang Guei-Jane Wang Guei-Jane Wang Hsiu-Chen Lin Jeng-Ren Duann Jeng-Ren Duann Chon-Haw Tsai Chon-Haw Tsai Chon-Haw Tsai Chon-Haw Tsai |
spellingShingle |
Hui-Chun Huang Hui-Chun Huang Hui-Chun Huang Hui-Chun Huang Hui-Chun Huang Chun-Ming Chen Chun-Ming Chen Ming-Kuei Lu Ming-Kuei Lu Ming-Kuei Lu Ming-Kuei Lu Bey-Ling Liu Chia-Ing Li Jui-Cheng Chen Jui-Cheng Chen Jui-Cheng Chen Jui-Cheng Chen Jui-Cheng Chen Guei-Jane Wang Guei-Jane Wang Guei-Jane Wang Guei-Jane Wang Hsiu-Chen Lin Jeng-Ren Duann Jeng-Ren Duann Chon-Haw Tsai Chon-Haw Tsai Chon-Haw Tsai Chon-Haw Tsai Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of Gait Frontiers in Aging Neuroscience Parkinson's disease freezing of gait motor imagery functional magnetic resonance imaging gait disorders |
author_facet |
Hui-Chun Huang Hui-Chun Huang Hui-Chun Huang Hui-Chun Huang Hui-Chun Huang Chun-Ming Chen Chun-Ming Chen Ming-Kuei Lu Ming-Kuei Lu Ming-Kuei Lu Ming-Kuei Lu Bey-Ling Liu Chia-Ing Li Jui-Cheng Chen Jui-Cheng Chen Jui-Cheng Chen Jui-Cheng Chen Jui-Cheng Chen Guei-Jane Wang Guei-Jane Wang Guei-Jane Wang Guei-Jane Wang Hsiu-Chen Lin Jeng-Ren Duann Jeng-Ren Duann Chon-Haw Tsai Chon-Haw Tsai Chon-Haw Tsai Chon-Haw Tsai |
author_sort |
Hui-Chun Huang |
title |
Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of Gait |
title_short |
Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of Gait |
title_full |
Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of Gait |
title_fullStr |
Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of Gait |
title_full_unstemmed |
Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of Gait |
title_sort |
gait-related brain activation during motor imagery of complex and simple ambulation in parkinson's disease with freezing of gait |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2021-09-01 |
description |
Background: Freezing of gait (FOG) in Parkinson's disease (PD) is a devastating clinical phenomenon that has a detrimental impact on patients. It tends to be triggered more often during turning (complex) than during forwarding straight (simple) walking. The neural mechanism underlying this phenomenon remains unclear and requires further elucidation.Objective: To investigate the differences in cerebral functional magnetic resonance imaging responses between PD patients with and without FOG during explicitly video-guided motor imagery (MI) of various complex (normal, freezing) and simple (normal, freezing) walking conditions.Methods: We recruited 34 PD patients, namely, 20 with FOG and 14 without FOG, and 15 normal controls. Participants underwent video-guided MI of turning and straight walking, with and without freezing, while their brain blood oxygen level-dependent (BOLD) activities were measured. Gait analysis was performed.Results: While comparing FOG turning with FOG straight walking, freezers showed higher activation of the superior occipital gyrus, left precentral gyrus, and right postcentral gyrus compared with non-freezers. Normal controls also manifest similar findings compared with non-freezers, except no difference was noted in occipital gyrus activity between the two groups. Freezers also displayed a higher effect size in the locomotor regions than non-freezers during imagery of normal turning.Conclusions: Our findings suggest that freezers require a higher drive of cortical and locomotion regions to overcome the overinhibition of the pathways in freezers than in non-freezers. Compared with simple walking, increased dorsal visual pathway and deep locomotion region activities might play pivotal roles in tackling FOG in freezers during complex walking. |
topic |
Parkinson's disease freezing of gait motor imagery functional magnetic resonance imaging gait disorders |
url |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.731332/full |
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doaj-e4fae27977f34d2aa2e2137b6f11a5e42021-09-22T05:20:05ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-09-011310.3389/fnagi.2021.731332731332Gait-Related Brain Activation During Motor Imagery of Complex and Simple Ambulation in Parkinson's Disease With Freezing of GaitHui-Chun Huang0Hui-Chun Huang1Hui-Chun Huang2Hui-Chun Huang3Hui-Chun Huang4Chun-Ming Chen5Chun-Ming Chen6Ming-Kuei Lu7Ming-Kuei Lu8Ming-Kuei Lu9Ming-Kuei Lu10Bey-Ling Liu11Chia-Ing Li12Jui-Cheng Chen13Jui-Cheng Chen14Jui-Cheng Chen15Jui-Cheng Chen16Jui-Cheng Chen17Guei-Jane Wang18Guei-Jane Wang19Guei-Jane Wang20Guei-Jane Wang21Hsiu-Chen Lin22Jeng-Ren Duann23Jeng-Ren Duann24Chon-Haw Tsai25Chon-Haw Tsai26Chon-Haw Tsai27Chon-Haw Tsai28Graduate Institute of Clinical Medical Science, China Medical University, Taichung, TaiwanDivision of Parkinson's Disease and Movement Disorders, Department of Neurology, China Medical University Hospital, Taichung, TaiwanNeuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, TaiwanSchool of Medicine, College of Medicine, China Medical University, Taichung, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung, TaiwanDepartment of Medical Imaging, China Medical University Hospital, Taichung, TaiwanNeuroscience and Brain Disease Center, College of Medicine, China Medical University, Taichung, TaiwanDivision of Parkinson's Disease and Movement Disorders, Department of Neurology, China Medical University Hospital, Taichung, TaiwanNeuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung, TaiwanNeuroscience and Brain Disease Center, College of Medicine, China Medical University, Taichung, TaiwanNeuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, TaiwanDepartment of Medical Research, China Medical University Hospital, Taichung, TaiwanDivision of Parkinson's Disease and Movement Disorders, Department of Neurology, China Medical University Hospital, Taichung, TaiwanNeuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, TaiwanSchool of Medicine, College of Medicine, China Medical University, Taichung, TaiwanNeuroscience and Brain Disease Center, College of Medicine, China Medical University, Taichung, TaiwanDepartment of Neurology, China Medical University Hsinchu Hospital, Hsinchu, TaiwanGraduate Institute of Clinical Medical Science, China Medical University, Taichung, TaiwanGraduate Institute of Biomedical Sciences, China Medical University, Taichung, TaiwanDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan0Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan1Department of Physical Therapy, China Medical University, Taichung, Taiwan2Institute of Education, National Yang Ming Chiao Tung University, Hsinchu, Taiwan3Institute for Neural Computation, University of California, San Diego, La Jolla, CA, United StatesDivision of Parkinson's Disease and Movement Disorders, Department of Neurology, China Medical University Hospital, Taichung, TaiwanNeuroscience Laboratory, Department of Neurology, China Medical University Hospital, Taichung, TaiwanSchool of Medicine, College of Medicine, China Medical University, Taichung, TaiwanNeuroscience and Brain Disease Center, College of Medicine, China Medical University, Taichung, TaiwanBackground: Freezing of gait (FOG) in Parkinson's disease (PD) is a devastating clinical phenomenon that has a detrimental impact on patients. It tends to be triggered more often during turning (complex) than during forwarding straight (simple) walking. The neural mechanism underlying this phenomenon remains unclear and requires further elucidation.Objective: To investigate the differences in cerebral functional magnetic resonance imaging responses between PD patients with and without FOG during explicitly video-guided motor imagery (MI) of various complex (normal, freezing) and simple (normal, freezing) walking conditions.Methods: We recruited 34 PD patients, namely, 20 with FOG and 14 without FOG, and 15 normal controls. Participants underwent video-guided MI of turning and straight walking, with and without freezing, while their brain blood oxygen level-dependent (BOLD) activities were measured. Gait analysis was performed.Results: While comparing FOG turning with FOG straight walking, freezers showed higher activation of the superior occipital gyrus, left precentral gyrus, and right postcentral gyrus compared with non-freezers. Normal controls also manifest similar findings compared with non-freezers, except no difference was noted in occipital gyrus activity between the two groups. Freezers also displayed a higher effect size in the locomotor regions than non-freezers during imagery of normal turning.Conclusions: Our findings suggest that freezers require a higher drive of cortical and locomotion regions to overcome the overinhibition of the pathways in freezers than in non-freezers. Compared with simple walking, increased dorsal visual pathway and deep locomotion region activities might play pivotal roles in tackling FOG in freezers during complex walking.https://www.frontiersin.org/articles/10.3389/fnagi.2021.731332/fullParkinson's diseasefreezing of gaitmotor imageryfunctional magnetic resonance imaginggait disorders |