Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer
Objective To explore the association between the degree of fibrosis in fibrotic focus (FF) and the unfavorable clinicopathological prognostic features of breast cancer. Methods A total of 169 cases of breast invasive ductal carcinoma (IDC) were included in the study. Hematoxylin and eosin (H&E)...
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doaj-e4fce6760fd7482493071eab3711a2902020-11-25T01:50:11ZengPeerJ Inc.PeerJ2167-83592019-11-017e806710.7717/peerj.8067Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancerYongfu Li0Yuhan Wei1Wenjun Tang2Jingru Luo3Minghua Wang4Haifeng Lin5Hong Guo6Yuling Ma7Jun Zhang8Qin Li9Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, ChinaDepartment of Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, ChinaDepartment of Pathology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, ChinaDepartment of Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, ChinaDepartment of Surgery, Beijing Changping District Hospital of Traditional Medicine, Beijing, ChinaDepartment of Gynecology, Beijing Changping District Hospital of Traditional Medicine, Beijing, ChinaDepartment of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX, United States of AmericaDepartment of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaObjective To explore the association between the degree of fibrosis in fibrotic focus (FF) and the unfavorable clinicopathological prognostic features of breast cancer. Methods A total of 169 cases of breast invasive ductal carcinoma (IDC) were included in the study. Hematoxylin and eosin (H&E) staining was performed in the primary lesion of breast IDC and the degree of fibrosis in tumor-stromal FF was assessed. The association between the degree of fibrosis in FF and the well-known clinicopathologic features of breast cancer was investigated and the influence of the degree of fibrosis in FF on the survival was analyzed. Results Tumor size >2 cm (P = 0.023), vascular invasion (P = 0.011), lymphatic vessel invasion (P < 0.001) and HER-2+ (P = 0.032) were positively correlated with the degree of fibrosis in FF in breast IDC. The result of multivariate analysis showed that lymphatic vessel invasion was the only independent correlation factor of high fibrosis in FF in breast IDC (OR = 3.82, 95% CI[1.13 ∼ 12.82], P = 0.031). The Nottingham prognostic index (NPI) of high fibrosis in FF was significantly higher than that of mild and moderate fibrosis in FF in the no vascular infiltration subgroup, the no nerve infiltration subgroup, and the Luminal A subgroup (P = 0.014, 0.039, and 0.018; respectively). Conclusions The high fibrosis in FF is closely associated with the strong invasiveness and the high malignancy of breast IDC. The degree of fibrosis in FF might be considered as a very practical and meaningful pathological feature of breast cancer.https://peerj.com/articles/8067.pdfFibrosis Fibrotic focus Prognosis Breast cancer Breast invasive ductal carcinoma Tumor size |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yongfu Li Yuhan Wei Wenjun Tang Jingru Luo Minghua Wang Haifeng Lin Hong Guo Yuling Ma Jun Zhang Qin Li |
spellingShingle |
Yongfu Li Yuhan Wei Wenjun Tang Jingru Luo Minghua Wang Haifeng Lin Hong Guo Yuling Ma Jun Zhang Qin Li Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer PeerJ Fibrosis Fibrotic focus Prognosis Breast cancer Breast invasive ductal carcinoma Tumor size |
author_facet |
Yongfu Li Yuhan Wei Wenjun Tang Jingru Luo Minghua Wang Haifeng Lin Hong Guo Yuling Ma Jun Zhang Qin Li |
author_sort |
Yongfu Li |
title |
Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer |
title_short |
Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer |
title_full |
Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer |
title_fullStr |
Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer |
title_full_unstemmed |
Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer |
title_sort |
association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer |
publisher |
PeerJ Inc. |
series |
PeerJ |
issn |
2167-8359 |
publishDate |
2019-11-01 |
description |
Objective To explore the association between the degree of fibrosis in fibrotic focus (FF) and the unfavorable clinicopathological prognostic features of breast cancer. Methods A total of 169 cases of breast invasive ductal carcinoma (IDC) were included in the study. Hematoxylin and eosin (H&E) staining was performed in the primary lesion of breast IDC and the degree of fibrosis in tumor-stromal FF was assessed. The association between the degree of fibrosis in FF and the well-known clinicopathologic features of breast cancer was investigated and the influence of the degree of fibrosis in FF on the survival was analyzed. Results Tumor size >2 cm (P = 0.023), vascular invasion (P = 0.011), lymphatic vessel invasion (P < 0.001) and HER-2+ (P = 0.032) were positively correlated with the degree of fibrosis in FF in breast IDC. The result of multivariate analysis showed that lymphatic vessel invasion was the only independent correlation factor of high fibrosis in FF in breast IDC (OR = 3.82, 95% CI[1.13 ∼ 12.82], P = 0.031). The Nottingham prognostic index (NPI) of high fibrosis in FF was significantly higher than that of mild and moderate fibrosis in FF in the no vascular infiltration subgroup, the no nerve infiltration subgroup, and the Luminal A subgroup (P = 0.014, 0.039, and 0.018; respectively). Conclusions The high fibrosis in FF is closely associated with the strong invasiveness and the high malignancy of breast IDC. The degree of fibrosis in FF might be considered as a very practical and meaningful pathological feature of breast cancer. |
topic |
Fibrosis Fibrotic focus Prognosis Breast cancer Breast invasive ductal carcinoma Tumor size |
url |
https://peerj.com/articles/8067.pdf |
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