Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism
ABSTRACT Objectives To describe the findings of thyroid ultrasonography (T-US), its contribution to diagnose congenital hypothyroidism (CH) and the best time to perform it. Subjects and methods Forty-four patients with CH were invited to undergo T-US and 41 accepted. Age ranged from 2 months to...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Brazilian Society of Endocrinology and Metabolism
2017-02-01
|
Series: | Archives of Endocrinology and Metabolism |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000500432&lng=en&tlng=en |
id |
doaj-e4ff949904bb4643a6288998b1927bdb |
---|---|
record_format |
Article |
spelling |
doaj-e4ff949904bb4643a6288998b1927bdb2020-11-24T23:58:42ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922017-02-0161543243710.1590/2359-3997000000239S2359-39972017000500432Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidismMaria de Fátima BorgesNathalie de Almeida SedassariAnelise de Almeida SedassariLuis Ronan Marquez Ferreira de SouzaBeatriz Pires FerreiraBeatriz Hallal Jorge LaraHeloísa Marcelina Cunha PalharesABSTRACT Objectives To describe the findings of thyroid ultrasonography (T-US), its contribution to diagnose congenital hypothyroidism (CH) and the best time to perform it. Subjects and methods Forty-four patients with CH were invited to undergo T-US and 41 accepted. Age ranged from 2 months to 45 years; 23 patients were females. All were treated with L-thyroxine; 16 had previously undergone scintigraphy and 30 had previous T-US, which were compared to current ones. Results At the current T-US, the thyroid gland was not visualized in its normal topography in 10 patients (24.5%); 31 T-US showed topic thyroid, 17 with normal or increased volume due to probable dyshormonogenesis, 13 cases of hypoplasia and one case of left-lobe hemiagenesis. One patient had decreased volume due to central hypothyroidism. Scintigraphy scans performed 3-4 years earlier showed 100% agreement with current results. Comparisons with previous T-US showed concordant results regarding thyroid location, but a decrease in current volume was observed in eight due to the use of L-thyroxine, calling the diagnosis of hypoplasia into question. Conclusions The role of T-US goes beyond complementing scintigraphy results. It allows inferring the etiology of CH, but it must be performed in the first months of life. An accurate diagnosis of CH will be attained with molecular study and the T-US can guide this early assessment, without therapy withdrawal.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000500432&lng=en&tlng=enCongenital hypothyroidismthyroid dysgenesisthyroid ectopiadyshormonogenesisthyroid ultrasound |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria de Fátima Borges Nathalie de Almeida Sedassari Anelise de Almeida Sedassari Luis Ronan Marquez Ferreira de Souza Beatriz Pires Ferreira Beatriz Hallal Jorge Lara Heloísa Marcelina Cunha Palhares |
spellingShingle |
Maria de Fátima Borges Nathalie de Almeida Sedassari Anelise de Almeida Sedassari Luis Ronan Marquez Ferreira de Souza Beatriz Pires Ferreira Beatriz Hallal Jorge Lara Heloísa Marcelina Cunha Palhares Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism Archives of Endocrinology and Metabolism Congenital hypothyroidism thyroid dysgenesis thyroid ectopia dyshormonogenesis thyroid ultrasound |
author_facet |
Maria de Fátima Borges Nathalie de Almeida Sedassari Anelise de Almeida Sedassari Luis Ronan Marquez Ferreira de Souza Beatriz Pires Ferreira Beatriz Hallal Jorge Lara Heloísa Marcelina Cunha Palhares |
author_sort |
Maria de Fátima Borges |
title |
Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism |
title_short |
Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism |
title_full |
Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism |
title_fullStr |
Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism |
title_full_unstemmed |
Timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism |
title_sort |
timing of thyroid ultrasonography in the etiological investigation of congenital hypothyroidism |
publisher |
Brazilian Society of Endocrinology and Metabolism |
series |
Archives of Endocrinology and Metabolism |
issn |
2359-4292 |
publishDate |
2017-02-01 |
description |
ABSTRACT Objectives To describe the findings of thyroid ultrasonography (T-US), its contribution to diagnose congenital hypothyroidism (CH) and the best time to perform it. Subjects and methods Forty-four patients with CH were invited to undergo T-US and 41 accepted. Age ranged from 2 months to 45 years; 23 patients were females. All were treated with L-thyroxine; 16 had previously undergone scintigraphy and 30 had previous T-US, which were compared to current ones. Results At the current T-US, the thyroid gland was not visualized in its normal topography in 10 patients (24.5%); 31 T-US showed topic thyroid, 17 with normal or increased volume due to probable dyshormonogenesis, 13 cases of hypoplasia and one case of left-lobe hemiagenesis. One patient had decreased volume due to central hypothyroidism. Scintigraphy scans performed 3-4 years earlier showed 100% agreement with current results. Comparisons with previous T-US showed concordant results regarding thyroid location, but a decrease in current volume was observed in eight due to the use of L-thyroxine, calling the diagnosis of hypoplasia into question. Conclusions The role of T-US goes beyond complementing scintigraphy results. It allows inferring the etiology of CH, but it must be performed in the first months of life. An accurate diagnosis of CH will be attained with molecular study and the T-US can guide this early assessment, without therapy withdrawal. |
topic |
Congenital hypothyroidism thyroid dysgenesis thyroid ectopia dyshormonogenesis thyroid ultrasound |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000500432&lng=en&tlng=en |
work_keys_str_mv |
AT mariadefatimaborges timingofthyroidultrasonographyintheetiologicalinvestigationofcongenitalhypothyroidism AT nathaliedealmeidasedassari timingofthyroidultrasonographyintheetiologicalinvestigationofcongenitalhypothyroidism AT anelisedealmeidasedassari timingofthyroidultrasonographyintheetiologicalinvestigationofcongenitalhypothyroidism AT luisronanmarquezferreiradesouza timingofthyroidultrasonographyintheetiologicalinvestigationofcongenitalhypothyroidism AT beatrizpiresferreira timingofthyroidultrasonographyintheetiologicalinvestigationofcongenitalhypothyroidism AT beatrizhallaljorgelara timingofthyroidultrasonographyintheetiologicalinvestigationofcongenitalhypothyroidism AT heloisamarcelinacunhapalhares timingofthyroidultrasonographyintheetiologicalinvestigationofcongenitalhypothyroidism |
_version_ |
1725450179252846592 |