Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease

Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease

Background: Parkinson’s Disease patients undergo time-consuming programming to refine stimulation parameters after deep brain stimulation surgery. Objective: To assess whether the use of the advanced functions of a patient’s programmer would facilitate programming of deep brain stimulation. Methods:...

Full description

Bibliographic Details
Main Authors: Lais M. Oliveira, Marta Ruiz-Lopez, Alexandre Boutet, Gavin J.B. Elias, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Renato P. Munhoz, Alfonso Fasano
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Brain Stimulation
Subjects:
Deep brain stimulation
Parkinson disease
Surgery
Therapy
Programming
Online Access:http://www.sciencedirect.com/science/article/pii/S1935861X21000711
id doaj-e507c07e5aa747e69b535b34226b5e42
record_format Article
spelling doaj-e507c07e5aa747e69b535b34226b5e422021-05-26T04:25:41ZengElsevierBrain Stimulation1935-861X2021-05-01143676681Self-adjustment of deep brain stimulation delays optimization in Parkinson’s diseaseLais M. Oliveira0Marta Ruiz-Lopez1Alexandre Boutet2Gavin J.B. Elias3Suneil K. Kalia4Mojgan Hodaie5Andres M. Lozano6Renato P. Munhoz7Alfonso Fasano8Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, CanadaEdmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Neurology Department, Cruces University Hospital, Barakaldo, Bizkaia, SpainDivision of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, CanadaDivision of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, CanadaDivision of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, CanadaDivision of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, CanadaDivision of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, CanadaEdmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, CanadaEdmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada; Corresponding author. Edmond J. Safra Program in Parkinson’s Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.Background: Parkinson’s Disease patients undergo time-consuming programming to refine stimulation parameters after deep brain stimulation surgery. Objective: To assess whether the use of the advanced functions of a patient’s programmer would facilitate programming of deep brain stimulation. Methods: Thirty patients were randomly allocated to the use of advanced versus simple mode of the patient programmer in this single-centre, prospective, randomized, controlled study. Primary outcome was the number of days required to optimize the stimulation settings. Results: The number of days required to optimize stimulation was significantly lower in the simple mode (88.5 ± 33.1 vs. 142.1 ± 67.4, p = 0.01). In addition, the advanced mode group had a higher number of side effects (5.4 ± 3.1 vs. 2.6 ± 1.9, p = 0.0055). Conclusions: The use of the advanced functions of patient programmer delays programming optimization and it is associated with a higher number of side effects. These findings highlight the need for other methods for faster and safer stimulation programming.http://www.sciencedirect.com/science/article/pii/S1935861X21000711Deep brain stimulationParkinson diseaseSurgeryTherapyProgramming
collection DOAJ
language English
format Article
sources DOAJ
author Lais M. Oliveira
Marta Ruiz-Lopez
Alexandre Boutet
Gavin J.B. Elias
Suneil K. Kalia
Mojgan Hodaie
Andres M. Lozano
Renato P. Munhoz
Alfonso Fasano
spellingShingle Lais M. Oliveira
Marta Ruiz-Lopez
Alexandre Boutet
Gavin J.B. Elias
Suneil K. Kalia
Mojgan Hodaie
Andres M. Lozano
Renato P. Munhoz
Alfonso Fasano
Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease
Brain Stimulation
Deep brain stimulation
Parkinson disease
Surgery
Therapy
Programming
author_facet Lais M. Oliveira
Marta Ruiz-Lopez
Alexandre Boutet
Gavin J.B. Elias
Suneil K. Kalia
Mojgan Hodaie
Andres M. Lozano
Renato P. Munhoz
Alfonso Fasano
author_sort Lais M. Oliveira
title Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease
title_short Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease
title_full Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease
title_fullStr Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease
title_full_unstemmed Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease
title_sort self-adjustment of deep brain stimulation delays optimization in parkinson’s disease
publisher Elsevier
series Brain Stimulation
issn 1935-861X
publishDate 2021-05-01
description Background: Parkinson’s Disease patients undergo time-consuming programming to refine stimulation parameters after deep brain stimulation surgery. Objective: To assess whether the use of the advanced functions of a patient’s programmer would facilitate programming of deep brain stimulation. Methods: Thirty patients were randomly allocated to the use of advanced versus simple mode of the patient programmer in this single-centre, prospective, randomized, controlled study. Primary outcome was the number of days required to optimize the stimulation settings. Results: The number of days required to optimize stimulation was significantly lower in the simple mode (88.5 ± 33.1 vs. 142.1 ± 67.4, p = 0.01). In addition, the advanced mode group had a higher number of side effects (5.4 ± 3.1 vs. 2.6 ± 1.9, p = 0.0055). Conclusions: The use of the advanced functions of patient programmer delays programming optimization and it is associated with a higher number of side effects. These findings highlight the need for other methods for faster and safer stimulation programming.
topic Deep brain stimulation
Parkinson disease
Surgery
Therapy
Programming
url http://www.sciencedirect.com/science/article/pii/S1935861X21000711
work_keys_str_mv AT laismoliveira selfadjustmentofdeepbrainstimulationdelaysoptimizationinparkinsonsdisease
AT martaruizlopez selfadjustmentofdeepbrainstimulationdelaysoptimizationinparkinsonsdisease
AT alexandreboutet selfadjustmentofdeepbrainstimulationdelaysoptimizationinparkinsonsdisease
AT gavinjbelias selfadjustmentofdeepbrainstimulationdelaysoptimizationinparkinsonsdisease
AT suneilkkalia selfadjustmentofdeepbrainstimulationdelaysoptimizationinparkinsonsdisease
AT mojganhodaie selfadjustmentofdeepbrainstimulationdelaysoptimizationinparkinsonsdisease
AT andresmlozano selfadjustmentofdeepbrainstimulationdelaysoptimizationinparkinsonsdisease
AT renatopmunhoz selfadjustmentofdeepbrainstimulationdelaysoptimizationinparkinsonsdisease
AT alfonsofasano selfadjustmentofdeepbrainstimulationdelaysoptimizationinparkinsonsdisease
_version_ 1721426772436713472

Similar Items