Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease
Background: Parkinson’s Disease patients undergo time-consuming programming to refine stimulation parameters after deep brain stimulation surgery. Objective: To assess whether the use of the advanced functions of a patient’s programmer would facilitate programming of deep brain stimulation. Methods:...
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doaj-e507c07e5aa747e69b535b34226b5e422021-05-26T04:25:41ZengElsevierBrain Stimulation1935-861X2021-05-01143676681Self-adjustment of deep brain stimulation delays optimization in Parkinson’s diseaseLais M. Oliveira0Marta Ruiz-Lopez1Alexandre Boutet2Gavin J.B. Elias3Suneil K. Kalia4Mojgan Hodaie5Andres M. Lozano6Renato P. Munhoz7Alfonso Fasano8Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, CanadaEdmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Neurology Department, Cruces University Hospital, Barakaldo, Bizkaia, SpainDivision of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, CanadaDivision of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, CanadaDivision of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, CanadaDivision of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, CanadaDivision of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, CanadaEdmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, CanadaEdmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada; Corresponding author. Edmond J. Safra Program in Parkinson’s Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.Background: Parkinson’s Disease patients undergo time-consuming programming to refine stimulation parameters after deep brain stimulation surgery. Objective: To assess whether the use of the advanced functions of a patient’s programmer would facilitate programming of deep brain stimulation. Methods: Thirty patients were randomly allocated to the use of advanced versus simple mode of the patient programmer in this single-centre, prospective, randomized, controlled study. Primary outcome was the number of days required to optimize the stimulation settings. Results: The number of days required to optimize stimulation was significantly lower in the simple mode (88.5 ± 33.1 vs. 142.1 ± 67.4, p = 0.01). In addition, the advanced mode group had a higher number of side effects (5.4 ± 3.1 vs. 2.6 ± 1.9, p = 0.0055). Conclusions: The use of the advanced functions of patient programmer delays programming optimization and it is associated with a higher number of side effects. These findings highlight the need for other methods for faster and safer stimulation programming.http://www.sciencedirect.com/science/article/pii/S1935861X21000711Deep brain stimulationParkinson diseaseSurgeryTherapyProgramming |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lais M. Oliveira Marta Ruiz-Lopez Alexandre Boutet Gavin J.B. Elias Suneil K. Kalia Mojgan Hodaie Andres M. Lozano Renato P. Munhoz Alfonso Fasano |
spellingShingle |
Lais M. Oliveira Marta Ruiz-Lopez Alexandre Boutet Gavin J.B. Elias Suneil K. Kalia Mojgan Hodaie Andres M. Lozano Renato P. Munhoz Alfonso Fasano Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease Brain Stimulation Deep brain stimulation Parkinson disease Surgery Therapy Programming |
author_facet |
Lais M. Oliveira Marta Ruiz-Lopez Alexandre Boutet Gavin J.B. Elias Suneil K. Kalia Mojgan Hodaie Andres M. Lozano Renato P. Munhoz Alfonso Fasano |
author_sort |
Lais M. Oliveira |
title |
Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease |
title_short |
Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease |
title_full |
Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease |
title_fullStr |
Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease |
title_full_unstemmed |
Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease |
title_sort |
self-adjustment of deep brain stimulation delays optimization in parkinson’s disease |
publisher |
Elsevier |
series |
Brain Stimulation |
issn |
1935-861X |
publishDate |
2021-05-01 |
description |
Background: Parkinson’s Disease patients undergo time-consuming programming to refine stimulation parameters after deep brain stimulation surgery. Objective: To assess whether the use of the advanced functions of a patient’s programmer would facilitate programming of deep brain stimulation. Methods: Thirty patients were randomly allocated to the use of advanced versus simple mode of the patient programmer in this single-centre, prospective, randomized, controlled study. Primary outcome was the number of days required to optimize the stimulation settings. Results: The number of days required to optimize stimulation was significantly lower in the simple mode (88.5 ± 33.1 vs. 142.1 ± 67.4, p = 0.01). In addition, the advanced mode group had a higher number of side effects (5.4 ± 3.1 vs. 2.6 ± 1.9, p = 0.0055). Conclusions: The use of the advanced functions of patient programmer delays programming optimization and it is associated with a higher number of side effects. These findings highlight the need for other methods for faster and safer stimulation programming. |
topic |
Deep brain stimulation Parkinson disease Surgery Therapy Programming |
url |
http://www.sciencedirect.com/science/article/pii/S1935861X21000711 |
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