GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells

GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells

Due to its importance in the pathogenesis of oral squamous cell carcinoma (OSCC), the Hedgehog (HH) pathway is considered a potential therapeutic target. We investigated the effects of GANT61, a GLI inhibitor, on HH gene expression, as well as on metastatic OSCC cell proliferation and death. Followi...

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Bibliographic Details
Main Authors: Taís Bacelar Sacramento de Araújo, Leonardo de Oliveira Siquara da Rocha, Manuela Torres Andion Vidal, Paulo Lucas Cerqueira Coelho, Mitermayer Galvão dos Reis, Bruno Solano de Freitas Souza, Milena Botelho Pereira Soares, Thiago Almeida Pereira, Ricardo Della Coletta, Daniel Pereira Bezerra, Rosane Borges Dias, Clarissa Araújo Gurgel Rocha
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
oral neoplasms
Hedgehog signaling pathway
Hedgehog signaling inhibitors
targeted cancer therapy
Online Access:https://www.mdpi.com/1422-0067/21/17/6076

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