Factors associated with TBS worse than BMD in non-osteoporotic elderly population: Bushehr elderly health program

• Main Authors: Nekoo Panahi, Afshin Ostovar, Noushin Fahimfar, Hamid Reza Aghaei Meybodi, Safoora Gharibzadeh, Babak Arjmand, Mahnaz Sanjari, Kazem Khalagi, Ramin Heshmat, Iraj Nabipour, Akbar Soltani, Bagher Larijani
• Format: Article
• Language: English
• Published: BMC 2021-07-01
• Series: BMC Geriatrics
• Subjects: Bone mineral density; Trabecular bone score; Osteoporosis; Discordance; Men; Women
• Online Access: https://doi.org/10.1186/s12877-021-02375-8

Abstract Background Bone mineral density (BMD) and trabecular bone score (TBS) are moderately correlated. TBS is sometimes used as an adjuvant to BMD in the fracture risk assessment. Some individuals with normal BMD or osteopenia, have more degraded TBS. We aimed to identify factors associated with TBS worse than BMD in the non-osteoporotic elderly population. Methods The study subjects were selected from 2384 women and men aged ≥60 years participating in the second stage of the Bushehr Elderly Health program, a population-based prospective cohort study in Iran. The BMDs of different sites and the lumbar spine texture were measured using dual-energy X-ray absorptiometry and the TBS algorithm, respectively. Subjects were categorized based on their BMD and TBS status. Logistic regression was performed to identify the factors associated with “TBS worse than BMD” in non-osteoporotic individuals. Results Of 1335 participants included in the study, 112 of 457 women, and 54 of 878 men had worse TBS than BMD. In multivariable analysis, TBS worse than BMD in women was statistically significantly associated with years since menopause (OR: 1.04 (1.00–1.07)) and waist circumference (OR: 1.09 (1.05–1.14)). However, in men, the condition was statistically significantly associated with waist circumference (OR: 1.10 (1.03–1.17)), current smoking (OR: 2.54 (1.10–5.84)), and HDL-C (OR: 1.03 (1.00–1.06)). Conclusion The results of the study show that higher waist circumference is associated with more degraded TBS than BMD in both men and women. Years passed since menopause and current smoking, respectively in women and men, were associated with more degraded TBS. Considering TBS values in older individuals with higher waist circumference, or a history of smoking despite normal BMDs might help more accurate assessment of bone health. However, further studies are required to confirm the benefit.