1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione
A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields and no further purification. Therefore, the proposed method, with an overall yield of 60%, offers a fac...
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MDPI AG
2021-06-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2021/2/M1228 |
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doaj-e5213cea7cb64ad792399638978a88392021-06-30T23:21:50ZengMDPI AGMolbank1422-85992021-06-012021M1228M122810.3390/M12281-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dioneVasiliki Pardali0Sotirios Katsamakas1Erofili Giannakopoulou2Grigoris Zoidis3Department of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceDepartment of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceDepartment of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceDepartment of Pharmacy, Division of Pharmaceutical Chemistry, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceA simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields and no further purification. Therefore, the proposed method, with an overall yield of 60%, offers a facile pathway to the synthesis of N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute a privileged class of heterocyclic scaffolds with pharmacological interest.https://www.mdpi.com/1422-8599/2021/2/M1228carbocyclic hydantoinsN-1 substituted hydantoinspiro hydantoinsimidazolidine-2,4-dionesDFT calculationsstereochemistry |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Vasiliki Pardali Sotirios Katsamakas Erofili Giannakopoulou Grigoris Zoidis |
| spellingShingle |
Vasiliki Pardali Sotirios Katsamakas Erofili Giannakopoulou Grigoris Zoidis 1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione Molbank carbocyclic hydantoins N-1 substituted hydantoin spiro hydantoins imidazolidine-2,4-diones DFT calculations stereochemistry |
| author_facet |
Vasiliki Pardali Sotirios Katsamakas Erofili Giannakopoulou Grigoris Zoidis |
| author_sort |
Vasiliki Pardali |
| title |
1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione |
| title_short |
1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione |
| title_full |
1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione |
| title_fullStr |
1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione |
| title_full_unstemmed |
1-Methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione |
| title_sort |
1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione |
| publisher |
MDPI AG |
| series |
Molbank |
| issn |
1422-8599 |
| publishDate |
2021-06-01 |
| description |
A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields and no further purification. Therefore, the proposed method, with an overall yield of 60%, offers a facile pathway to the synthesis of N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute a privileged class of heterocyclic scaffolds with pharmacological interest. |
| topic |
carbocyclic hydantoins N-1 substituted hydantoin spiro hydantoins imidazolidine-2,4-diones DFT calculations stereochemistry |
| url |
https://www.mdpi.com/1422-8599/2021/2/M1228 |
| work_keys_str_mv |
AT vasilikipardali 1methyl8phenyl13diazaspiro45decane24dione AT sotirioskatsamakas 1methyl8phenyl13diazaspiro45decane24dione AT erofiligiannakopoulou 1methyl8phenyl13diazaspiro45decane24dione AT grigoriszoidis 1methyl8phenyl13diazaspiro45decane24dione |
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1721351612071411712 |