Primary epiglottic follicular variant of peripheral T-cell lymphoma
The follicular variant of peripheral T-cell lymphoma, not otherwise specified, is very rare. Primary epiglottic follicular variant of peripheral T-cell lymphoma is extremely rare in clinical practice. Here, we report the first case of a follicular variant of peripheral T-cell lymphoma not otherwise...
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2019-01-01
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doaj-e5287de62bb34201aabaf215d76bb0a22020-11-25T02:39:24ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292019-01-0162458658810.4103/IJPM.IJPM_849_18Primary epiglottic follicular variant of peripheral T-cell lymphomaJienan KongLin ZhongXue GaoWenjing QiLizhi ZhangZhenhua LinThe follicular variant of peripheral T-cell lymphoma, not otherwise specified, is very rare. Primary epiglottic follicular variant of peripheral T-cell lymphoma is extremely rare in clinical practice. Here, we report the first case of a follicular variant of peripheral T-cell lymphoma not otherwise specified in a 44-year-old Chinese man, who presented with a tumor in the middle of the epiglottis tongue surface. Microscopically, the tumor had a vague nodular growth pattern and the morphology of the nodules was different from each other at low power. Atypical lymphoid cells were medium to large in size and had round nuclei, with an irregular nuclear membrane, distinct nucleoli, and rapid mitotic activity. Plasma cells were found surrounding the nodules. The tumor cells were positive for follicular helper T-cell markers (CD10, PD-1, CXCL13, and BCL-6). The EBER was negative by in situ hybridization. Polymerase chain reaction-based analysis showed monoclonal rearrangements of TCRβ, TCRγ, and polyclonal rearrangements of IgH, IgK, and IgL. The clinical and imaging features and the prognostic factors of FV PTCL-NOS remain poorly understood. Thus, investigation of more cases and longer follow-up is necessary to understand the disease and to identify the best treatment to improve prognosis.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=4;spage=586;epage=588;aulast=KongEpiglottisfollicular T-helper cellsfollicular variant PTCL |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jienan Kong Lin Zhong Xue Gao Wenjing Qi Lizhi Zhang Zhenhua Lin |
spellingShingle |
Jienan Kong Lin Zhong Xue Gao Wenjing Qi Lizhi Zhang Zhenhua Lin Primary epiglottic follicular variant of peripheral T-cell lymphoma Indian Journal of Pathology and Microbiology Epiglottis follicular T-helper cells follicular variant PTCL |
author_facet |
Jienan Kong Lin Zhong Xue Gao Wenjing Qi Lizhi Zhang Zhenhua Lin |
author_sort |
Jienan Kong |
title |
Primary epiglottic follicular variant of peripheral T-cell lymphoma |
title_short |
Primary epiglottic follicular variant of peripheral T-cell lymphoma |
title_full |
Primary epiglottic follicular variant of peripheral T-cell lymphoma |
title_fullStr |
Primary epiglottic follicular variant of peripheral T-cell lymphoma |
title_full_unstemmed |
Primary epiglottic follicular variant of peripheral T-cell lymphoma |
title_sort |
primary epiglottic follicular variant of peripheral t-cell lymphoma |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Pathology and Microbiology |
issn |
0377-4929 |
publishDate |
2019-01-01 |
description |
The follicular variant of peripheral T-cell lymphoma, not otherwise specified, is very rare. Primary epiglottic follicular variant of peripheral T-cell lymphoma is extremely rare in clinical practice. Here, we report the first case of a follicular variant of peripheral T-cell lymphoma not otherwise specified in a 44-year-old Chinese man, who presented with a tumor in the middle of the epiglottis tongue surface. Microscopically, the tumor had a vague nodular growth pattern and the morphology of the nodules was different from each other at low power. Atypical lymphoid cells were medium to large in size and had round nuclei, with an irregular nuclear membrane, distinct nucleoli, and rapid mitotic activity. Plasma cells were found surrounding the nodules. The tumor cells were positive for follicular helper T-cell markers (CD10, PD-1, CXCL13, and BCL-6). The EBER was negative by in situ hybridization. Polymerase chain reaction-based analysis showed monoclonal rearrangements of TCRβ, TCRγ, and polyclonal rearrangements of IgH, IgK, and IgL. The clinical and imaging features and the prognostic factors of FV PTCL-NOS remain poorly understood. Thus, investigation of more cases and longer follow-up is necessary to understand the disease and to identify the best treatment to improve prognosis. |
topic |
Epiglottis follicular T-helper cells follicular variant PTCL |
url |
http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2019;volume=62;issue=4;spage=586;epage=588;aulast=Kong |
work_keys_str_mv |
AT jienankong primaryepiglotticfollicularvariantofperipheraltcelllymphoma AT linzhong primaryepiglotticfollicularvariantofperipheraltcelllymphoma AT xuegao primaryepiglotticfollicularvariantofperipheraltcelllymphoma AT wenjingqi primaryepiglotticfollicularvariantofperipheraltcelllymphoma AT lizhizhang primaryepiglotticfollicularvariantofperipheraltcelllymphoma AT zhenhualin primaryepiglotticfollicularvariantofperipheraltcelllymphoma |
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