DNA Copy Number Variations as Markers of Mutagenic Impact

DNA Copy Number Variations as Markers of Mutagenic Impact

DNA copy number variation (CNV) occurs due to deletion or duplication of DNA segments resulting in a different number of copies of a specific DNA-stretch on homologous chromosomes. Implications of CNVs in evolution and development of different diseases have been demonstrated although contribution of...

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Main Authors: Galina Hovhannisyan, Tigran Harutyunyan, Rouben Aroutiounian, Thomas Liehr
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
copy number variation
human
animal and plant cells
chemical mutagens
radiation
Online Access:https://www.mdpi.com/1422-0067/20/19/4723
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spelling doaj-e530e84429ca4e57b7a781eb0242ceab2020-11-24T21:20:55ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-09-012019472310.3390/ijms20194723ijms20194723DNA Copy Number Variations as Markers of Mutagenic ImpactGalina Hovhannisyan0Tigran Harutyunyan1Rouben Aroutiounian2Thomas Liehr3Department of Genetics and Cytology, Yerevan State University, Alex Manoogian 1, 0025 Yerevan, ArmeniaDepartment of Genetics and Cytology, Yerevan State University, Alex Manoogian 1, 0025 Yerevan, ArmeniaDepartment of Genetics and Cytology, Yerevan State University, Alex Manoogian 1, 0025 Yerevan, ArmeniaInstitute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Am Klinikum 1, D-07747 Jena, GermanyDNA copy number variation (CNV) occurs due to deletion or duplication of DNA segments resulting in a different number of copies of a specific DNA-stretch on homologous chromosomes. Implications of CNVs in evolution and development of different diseases have been demonstrated although contribution of environmental factors, such as mutagens, in the origin of CNVs, is poorly understood. In this review, we summarize current knowledge about mutagen-induced CNVs in human, animal and plant cells. Differences in CNV frequencies induced by radiation and chemical mutagens, distribution of CNVs in the genome, as well as adaptive effects in plants, are discussed. Currently available information concerning impact of mutagens in induction of CNVs in germ cells is presented. Moreover, the potential of CNVs as a new endpoint in mutagenicity test-systems is discussed.https://www.mdpi.com/1422-0067/20/19/4723copy number variationhumananimal and plant cellschemical mutagensradiation
collection DOAJ
language English
format Article
sources DOAJ
author Galina Hovhannisyan
Tigran Harutyunyan
Rouben Aroutiounian
Thomas Liehr
spellingShingle Galina Hovhannisyan
Tigran Harutyunyan
Rouben Aroutiounian
Thomas Liehr
DNA Copy Number Variations as Markers of Mutagenic Impact
International Journal of Molecular Sciences
copy number variation
human
animal and plant cells
chemical mutagens
radiation
author_facet Galina Hovhannisyan
Tigran Harutyunyan
Rouben Aroutiounian
Thomas Liehr
author_sort Galina Hovhannisyan
title DNA Copy Number Variations as Markers of Mutagenic Impact
title_short DNA Copy Number Variations as Markers of Mutagenic Impact
title_full DNA Copy Number Variations as Markers of Mutagenic Impact
title_fullStr DNA Copy Number Variations as Markers of Mutagenic Impact
title_full_unstemmed DNA Copy Number Variations as Markers of Mutagenic Impact
title_sort dna copy number variations as markers of mutagenic impact
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2019-09-01
description DNA copy number variation (CNV) occurs due to deletion or duplication of DNA segments resulting in a different number of copies of a specific DNA-stretch on homologous chromosomes. Implications of CNVs in evolution and development of different diseases have been demonstrated although contribution of environmental factors, such as mutagens, in the origin of CNVs, is poorly understood. In this review, we summarize current knowledge about mutagen-induced CNVs in human, animal and plant cells. Differences in CNV frequencies induced by radiation and chemical mutagens, distribution of CNVs in the genome, as well as adaptive effects in plants, are discussed. Currently available information concerning impact of mutagens in induction of CNVs in germ cells is presented. Moreover, the potential of CNVs as a new endpoint in mutagenicity test-systems is discussed.
topic copy number variation
human
animal and plant cells
chemical mutagens
radiation
url https://www.mdpi.com/1422-0067/20/19/4723
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AT tigranharutyunyan dnacopynumbervariationsasmarkersofmutagenicimpact
AT roubenaroutiounian dnacopynumbervariationsasmarkersofmutagenicimpact
AT thomasliehr dnacopynumbervariationsasmarkersofmutagenicimpact
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