Allostatic Load Is Linked to Cortical Thickness Changes Depending on Body-Weight Status
Objective: Overweight (body mass index or BMI ≥ 25 kg/m2) and stress interact with each other in complex ways. Overweight promotes chronic low-inflammation states, while stress is known to mediate caloric intake. Both conditions are linked to several avoidable health problems and to cognitive declin...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2017-12-01
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Series: | Frontiers in Human Neuroscience |
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Online Access: | http://journal.frontiersin.org/article/10.3389/fnhum.2017.00639/full |
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English |
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Article |
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DOAJ |
author |
Jonatan Ottino-González Jonatan Ottino-González Jonatan Ottino-González María A. Jurado María A. Jurado María A. Jurado Isabel García-García Bàrbara Segura Bàrbara Segura Idoia Marqués-Iturria María J. Sender-Palacios María J. Sender-Palacios Encarnació Tor Encarnació Tor Xavier Prats-Soteras Xavier Prats-Soteras Xavier Prats-Soteras Xavier Caldú Xavier Caldú Xavier Caldú Carme Junqué Carme Junqué Carme Junqué Maite Garolera Maite Garolera |
spellingShingle |
Jonatan Ottino-González Jonatan Ottino-González Jonatan Ottino-González María A. Jurado María A. Jurado María A. Jurado Isabel García-García Bàrbara Segura Bàrbara Segura Idoia Marqués-Iturria María J. Sender-Palacios María J. Sender-Palacios Encarnació Tor Encarnació Tor Xavier Prats-Soteras Xavier Prats-Soteras Xavier Prats-Soteras Xavier Caldú Xavier Caldú Xavier Caldú Carme Junqué Carme Junqué Carme Junqué Maite Garolera Maite Garolera Allostatic Load Is Linked to Cortical Thickness Changes Depending on Body-Weight Status Frontiers in Human Neuroscience overweight obesity allostatic load chronic stress inflammation cortical thickness |
author_facet |
Jonatan Ottino-González Jonatan Ottino-González Jonatan Ottino-González María A. Jurado María A. Jurado María A. Jurado Isabel García-García Bàrbara Segura Bàrbara Segura Idoia Marqués-Iturria María J. Sender-Palacios María J. Sender-Palacios Encarnació Tor Encarnació Tor Xavier Prats-Soteras Xavier Prats-Soteras Xavier Prats-Soteras Xavier Caldú Xavier Caldú Xavier Caldú Carme Junqué Carme Junqué Carme Junqué Maite Garolera Maite Garolera |
author_sort |
Jonatan Ottino-González |
title |
Allostatic Load Is Linked to Cortical Thickness Changes Depending on Body-Weight Status |
title_short |
Allostatic Load Is Linked to Cortical Thickness Changes Depending on Body-Weight Status |
title_full |
Allostatic Load Is Linked to Cortical Thickness Changes Depending on Body-Weight Status |
title_fullStr |
Allostatic Load Is Linked to Cortical Thickness Changes Depending on Body-Weight Status |
title_full_unstemmed |
Allostatic Load Is Linked to Cortical Thickness Changes Depending on Body-Weight Status |
title_sort |
allostatic load is linked to cortical thickness changes depending on body-weight status |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Human Neuroscience |
issn |
1662-5161 |
publishDate |
2017-12-01 |
description |
Objective: Overweight (body mass index or BMI ≥ 25 kg/m2) and stress interact with each other in complex ways. Overweight promotes chronic low-inflammation states, while stress is known to mediate caloric intake. Both conditions are linked to several avoidable health problems and to cognitive decline, brain atrophy, and dementia. Since it was proposed as a framework for the onset of mental illness, the allostatic load model has received increasing attention. Although changes in health and cognition related to overweight and stress are well-documented separately, the association between allostatic load and brain integrity has not been addressed in depth, especially among overweight subjects.Method: Thirty-four healthy overweight-to-obese and 29 lean adults underwent blood testing, neuropsychological examination, and magnetic resonance imaging to assess the relationship between cortical thickness and allostatic load, represented as an index of 15 biomarkers (this is, systolic and diastolic arterial tension, glycated hemoglobin, glucose, creatinine, total cholesterol, HDL and LDL cholesterol, triglycerides, c-reactive protein, interleukin-6, insulin, cortisol, fibrinogen, and leptin).Results: Allostatic load indexes showed widespread positive and negative significant correlations (p < 0.01) with cortical thickness values depending on body-weight status.Conclusion: The increase of allostatic load is linked to changes in the gray matter composition of regions monitoring behavior, sensory-reward processing, and general cognitive function. |
topic |
overweight obesity allostatic load chronic stress inflammation cortical thickness |
url |
http://journal.frontiersin.org/article/10.3389/fnhum.2017.00639/full |
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doaj-e5329cb055c246459201c2e759f353672020-11-25T03:14:54ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612017-12-011110.3389/fnhum.2017.00639322749Allostatic Load Is Linked to Cortical Thickness Changes Depending on Body-Weight StatusJonatan Ottino-González0Jonatan Ottino-González1Jonatan Ottino-González2María A. Jurado3María A. Jurado4María A. Jurado5Isabel García-García6Bàrbara Segura7Bàrbara Segura8Idoia Marqués-Iturria9María J. Sender-Palacios10María J. Sender-Palacios11Encarnació Tor12Encarnació Tor13Xavier Prats-Soteras14Xavier Prats-Soteras15Xavier Prats-Soteras16Xavier Caldú17Xavier Caldú18Xavier Caldú19Carme Junqué20Carme Junqué21Carme Junqué22Maite Garolera23Maite Garolera24Departament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, SpainInstitut de Neurociències, Universitat de Barcelona, Barcelona, SpainInstitut de Recerca Pediàtrica Hospital Sant Joan de Déu, Barcelona, SpainDepartament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, SpainInstitut de Neurociències, Universitat de Barcelona, Barcelona, SpainInstitut de Recerca Pediàtrica Hospital Sant Joan de Déu, Barcelona, SpainMontreal Neurological Institute, McGill University, Montreal, QC, CanadaDepartament de Medicina, Universitat de Barcelona, Barcelona, SpainInstitut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, SpainDepartament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, SpainCAP Terrassa Nord, Consorci Sanitari de Terrassa, Barcelona, SpainBrain, Cognition and Behavior Clinical Research Group, Consorci Sanitari de Terrassa, Terrassa, SpainCAP Terrassa Nord, Consorci Sanitari de Terrassa, Barcelona, SpainBrain, Cognition and Behavior Clinical Research Group, Consorci Sanitari de Terrassa, Terrassa, SpainDepartament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, SpainInstitut de Neurociències, Universitat de Barcelona, Barcelona, SpainInstitut de Recerca Pediàtrica Hospital Sant Joan de Déu, Barcelona, SpainDepartament de Psicologia Clínica i Psicobiologia, Universitat de Barcelona, Barcelona, SpainInstitut de Neurociències, Universitat de Barcelona, Barcelona, SpainInstitut de Recerca Pediàtrica Hospital Sant Joan de Déu, Barcelona, SpainInstitut de Neurociències, Universitat de Barcelona, Barcelona, SpainDepartament de Medicina, Universitat de Barcelona, Barcelona, SpainInstitut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, SpainBrain, Cognition and Behavior Clinical Research Group, Consorci Sanitari de Terrassa, Terrassa, SpainUnitat de Neuropsicologia, Hospital de Terrassa, Consorci Sanitari de Terrassa, Barcelona, SpainObjective: Overweight (body mass index or BMI ≥ 25 kg/m2) and stress interact with each other in complex ways. Overweight promotes chronic low-inflammation states, while stress is known to mediate caloric intake. Both conditions are linked to several avoidable health problems and to cognitive decline, brain atrophy, and dementia. Since it was proposed as a framework for the onset of mental illness, the allostatic load model has received increasing attention. Although changes in health and cognition related to overweight and stress are well-documented separately, the association between allostatic load and brain integrity has not been addressed in depth, especially among overweight subjects.Method: Thirty-four healthy overweight-to-obese and 29 lean adults underwent blood testing, neuropsychological examination, and magnetic resonance imaging to assess the relationship between cortical thickness and allostatic load, represented as an index of 15 biomarkers (this is, systolic and diastolic arterial tension, glycated hemoglobin, glucose, creatinine, total cholesterol, HDL and LDL cholesterol, triglycerides, c-reactive protein, interleukin-6, insulin, cortisol, fibrinogen, and leptin).Results: Allostatic load indexes showed widespread positive and negative significant correlations (p < 0.01) with cortical thickness values depending on body-weight status.Conclusion: The increase of allostatic load is linked to changes in the gray matter composition of regions monitoring behavior, sensory-reward processing, and general cognitive function.http://journal.frontiersin.org/article/10.3389/fnhum.2017.00639/fulloverweightobesityallostatic loadchronic stressinflammationcortical thickness |