Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac origin
<p>Abstract</p> <p>Background</p> <p>Leiomyosarcoma occurring as a primary cardiac tumor has been known as an extremely rare condition. Previous studies of leiomyosarcoma with rhabdomyoblastic differentiation have conducted to those arisen from another site, and they in...
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doaj-e53441a34ba9407dbcb47c05d1560da02020-11-24T21:33:53ZengBMCBMC Cancer1471-24072011-02-011117610.1186/1471-2407-11-76Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac originHiruta NobuyukiShinozaki MinoruWakayama MegumiMitsuda AkiNemoto TetsuoKameda NoriakiTakamura KazuhisaNamiki AtsushiShibuya KazutoshiOkubo YoichiroKitahara KanakoIshiwatari TakaoYamazaki Junichi<p>Abstract</p> <p>Background</p> <p>Leiomyosarcoma occurring as a primary cardiac tumor has been known as an extremely rare condition. Previous studies of leiomyosarcoma with rhabdomyoblastic differentiation have conducted to those arisen from another site, and they indicated a poorer prognosis of this tumor.</p> <p>Case presentation</p> <p>A 69-year-old woman was referred to our hospital for an operation concerning umbilical hernia. Subsequent imaging examinations before an operation indicated the presence of primary cardiac malignant tumor due to its atypical shape. And then, it was surgically removed. Histopathologically, tumor cells consisted of two different types: spindle and polyhedral cells. Immunohistochemically, it is interesting to note that 2.1% of spindle cells and 23.1% of polyhedral cells showed positive reactivity for myogenin. Furthermore, we performed double-immunostaining for alpha-smooth muscle actin (SMA) and myogenin. The rates of alpha-SMA and myogenin double negative, alpha-SMA single positive, myogenin single positive, and alpha-SMA and myogenin double positive in spindle cells were estimated as 69.1%, 28.8%, 1.1% and 1.0%, respectively. In contrast, the rates in polyhedral cells were estimated as 76.9%, 0.0%, 23.1%, and 0.0%, respectively.</p> <p>Conclusion</p> <p>Our immunohistochemical evaluation suggested that rhabdomyoblastic differentiation in leiomyosarcoma might be generated not only by de novo generation from mesenchymal cells. To the best of our knowledge, this is the first case of primary cardiac leiomyosarcoma with partial rhabdomyoblastic differentiation.</p> http://www.biomedcentral.com/1471-2407/11/76 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiruta Nobuyuki Shinozaki Minoru Wakayama Megumi Mitsuda Aki Nemoto Tetsuo Kameda Noriaki Takamura Kazuhisa Namiki Atsushi Shibuya Kazutoshi Okubo Yoichiro Kitahara Kanako Ishiwatari Takao Yamazaki Junichi |
spellingShingle |
Hiruta Nobuyuki Shinozaki Minoru Wakayama Megumi Mitsuda Aki Nemoto Tetsuo Kameda Noriaki Takamura Kazuhisa Namiki Atsushi Shibuya Kazutoshi Okubo Yoichiro Kitahara Kanako Ishiwatari Takao Yamazaki Junichi Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac origin BMC Cancer |
author_facet |
Hiruta Nobuyuki Shinozaki Minoru Wakayama Megumi Mitsuda Aki Nemoto Tetsuo Kameda Noriaki Takamura Kazuhisa Namiki Atsushi Shibuya Kazutoshi Okubo Yoichiro Kitahara Kanako Ishiwatari Takao Yamazaki Junichi |
author_sort |
Hiruta Nobuyuki |
title |
Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac origin |
title_short |
Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac origin |
title_full |
Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac origin |
title_fullStr |
Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac origin |
title_full_unstemmed |
Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac origin |
title_sort |
leiomyosarcoma with partial rhabdomyoblastic differentiation: first case report of primary cardiac origin |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2011-02-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Leiomyosarcoma occurring as a primary cardiac tumor has been known as an extremely rare condition. Previous studies of leiomyosarcoma with rhabdomyoblastic differentiation have conducted to those arisen from another site, and they indicated a poorer prognosis of this tumor.</p> <p>Case presentation</p> <p>A 69-year-old woman was referred to our hospital for an operation concerning umbilical hernia. Subsequent imaging examinations before an operation indicated the presence of primary cardiac malignant tumor due to its atypical shape. And then, it was surgically removed. Histopathologically, tumor cells consisted of two different types: spindle and polyhedral cells. Immunohistochemically, it is interesting to note that 2.1% of spindle cells and 23.1% of polyhedral cells showed positive reactivity for myogenin. Furthermore, we performed double-immunostaining for alpha-smooth muscle actin (SMA) and myogenin. The rates of alpha-SMA and myogenin double negative, alpha-SMA single positive, myogenin single positive, and alpha-SMA and myogenin double positive in spindle cells were estimated as 69.1%, 28.8%, 1.1% and 1.0%, respectively. In contrast, the rates in polyhedral cells were estimated as 76.9%, 0.0%, 23.1%, and 0.0%, respectively.</p> <p>Conclusion</p> <p>Our immunohistochemical evaluation suggested that rhabdomyoblastic differentiation in leiomyosarcoma might be generated not only by de novo generation from mesenchymal cells. To the best of our knowledge, this is the first case of primary cardiac leiomyosarcoma with partial rhabdomyoblastic differentiation.</p> |
url |
http://www.biomedcentral.com/1471-2407/11/76 |
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