Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

<p>Abstract</p> <p>α-synuclein (α-syn) is a main component of Lewy bodies (LB) that occur in many neurodegenerative diseases, including Parkinson's disease (PD), dementia with LB (DLB) and multi-system atrophy. α-syn mutations or amplifications are responsible for a subset of...

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Main Authors: Qiao Liyan, Hamamichi Shusei, Caldwell Kim A, Caldwell Guy A, Yacoubian Talene A, Wilson Scott, Xie Zuo-Lei, Speake Lisa D, Parks Rachael, Crabtree Donna, Liang Qiuli, Crimmins Stephen, Schneider Lonnie, Uchiyama Yasuo, Iwatsubo Takeshi, Zhou Yi, Peng Lisheng, Lu YouMing, Standaert David G, Walls Ken C, Shacka John J, Roth Kevin A, Zhang Jianhua
Format: Article
Language:English
Published: BMC 2008-11-01
Series:Molecular Brain
Online Access:http://www.molecularbrain.com/content/1/1/17

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