The Association of a Rare Variant of -93, -53 Promoter Gene Polymorphisms of Lipoprotein Lipase Gene with Obesity and Insulin Resistance

• Main Authors: Jai Prakash, Balraj Mittal, Apurva Srivastava, Shally Awasthi, Neena Srivastava
• Format: Article
• Language: English
• Published: Oman Medical Specialty Board 2018-09-01
• Series: Oman Medical Journal
• Subjects: Obesity; Lipoprotein Lipase; Polymorphism; Genetic; Insulin Resistance; Diabetes Mellitus; India
• Online Access: http://omjournal.org/articleDetails.aspx?coType=1&aId=2163

Objectives: Obesity increases the risk of numerous chronic diseases. Obesity is classified clinically using body mass index (BMI), waist-to-hip ratio, and body fat percentage. The lipoprotein lipase (LPL) gene has been linked to lipoprotein metabolism and obesity. We performed a case-control study to determine the association between LPL gene polymorphisms and obesity-associated phenotypes such as insulin resistance (IR). Methods: We examined the different LPL gene variants for association in 642 individuals segregated by BMI and IR. Genotyping of the LPL gene -93 and -53 promoter gene polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism. Results: A substantial association was observed for -93 gene polymorphism of the LPL gene with obesity, while -53 promoter gene polymorphism showed association with IR. Conclusions: We found a significant association between -93 and -53 promoter gene polymorphisms of the LPL gene with obesity and associated phenotypes in the studied population.