Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure
Microbubbles are considered a promising tool for noninvasive estimation of local blood pressure. It is reported that the subharmonic scattering amplitude of microbubbles decreases by 9 to 12 dB when immersed in the media under an ambient pressure variation from 0 to 180 mmHg. However, the pressure s...
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doaj-e541a64966d444d8b86d5a6e699eff152020-11-24T23:32:57ZengMDPI AGSensors1424-82202018-11-011812408310.3390/s18124083s18124083Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient PressureFei Li0Deyu Li1Fei Yan2Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaSchool of Biological Science and Medical Engineering, Beihang University, Beijing 100083, ChinaPaul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaMicrobubbles are considered a promising tool for noninvasive estimation of local blood pressure. It is reported that the subharmonic scattering amplitude of microbubbles decreases by 9 to 12 dB when immersed in the media under an ambient pressure variation from 0 to 180 mmHg. However, the pressure sensitivity still needs to be improved to satisfy clinical diagnostic requirements. Here, we investigated the effects of acoustic parameters on the pressure sensitivity of microbubbles through measuring the acoustic attenuation and scattering properties of commercially available SonoVue microbubbles. Our results showed that the first harmonic, subharmonic, and ultraharmonic amplitudes of microbubbles were reduced by 6.6 dB, 10.9 dB, and 9.3 dB at 0.225 mechanical index (MI), 4.6 dB, 19.8 dB, and 12.3 dB at 0.25 MI, and 18.5 dB, 17.6 dB, and 12.6 dB at 0.3 MI, respectively, when the ambient pressure increased from 0 to 180 mmHg. Our finding revealed that a moderate MI (0.25⁻0.4) exciting microbubbles could significantly improve their sensitivities to detect ambient pressure.https://www.mdpi.com/1424-8220/18/12/4083microbubblespressure sensorsnoninvasive blood pressure measurementmechanical indexsubharmonic amplitude |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fei Li Deyu Li Fei Yan |
spellingShingle |
Fei Li Deyu Li Fei Yan Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure Sensors microbubbles pressure sensors noninvasive blood pressure measurement mechanical index subharmonic amplitude |
author_facet |
Fei Li Deyu Li Fei Yan |
author_sort |
Fei Li |
title |
Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure |
title_short |
Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure |
title_full |
Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure |
title_fullStr |
Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure |
title_full_unstemmed |
Improvement of Detection Sensitivity of Microbubbles as Sensors to Detect Ambient Pressure |
title_sort |
improvement of detection sensitivity of microbubbles as sensors to detect ambient pressure |
publisher |
MDPI AG |
series |
Sensors |
issn |
1424-8220 |
publishDate |
2018-11-01 |
description |
Microbubbles are considered a promising tool for noninvasive estimation of local blood pressure. It is reported that the subharmonic scattering amplitude of microbubbles decreases by 9 to 12 dB when immersed in the media under an ambient pressure variation from 0 to 180 mmHg. However, the pressure sensitivity still needs to be improved to satisfy clinical diagnostic requirements. Here, we investigated the effects of acoustic parameters on the pressure sensitivity of microbubbles through measuring the acoustic attenuation and scattering properties of commercially available SonoVue microbubbles. Our results showed that the first harmonic, subharmonic, and ultraharmonic amplitudes of microbubbles were reduced by 6.6 dB, 10.9 dB, and 9.3 dB at 0.225 mechanical index (MI), 4.6 dB, 19.8 dB, and 12.3 dB at 0.25 MI, and 18.5 dB, 17.6 dB, and 12.6 dB at 0.3 MI, respectively, when the ambient pressure increased from 0 to 180 mmHg. Our finding revealed that a moderate MI (0.25⁻0.4) exciting microbubbles could significantly improve their sensitivities to detect ambient pressure. |
topic |
microbubbles pressure sensors noninvasive blood pressure measurement mechanical index subharmonic amplitude |
url |
https://www.mdpi.com/1424-8220/18/12/4083 |
work_keys_str_mv |
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