CMC is more than a measure of corticospinal tract integrity in acute stroke patients
In healthy subjects, motor cortex activity and electromyographic (EMG) signals from contracting contralateral muscle show coherence in the beta (15–30 Hz) range. Corticomuscular coherence (CMC) is considered a sign of functional coupling between muscle and brain. Based on prior studies, CMC is alter...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-01-01
|
Series: | NeuroImage: Clinical |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S221315822100262X |
id |
doaj-e561ec87eac64581a130d263ab7503f2 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
R. Aikio K. Laaksonen V. Sairanen E. Parkkonen A. Abou Elseoud J. Kujala N. Forss |
spellingShingle |
R. Aikio K. Laaksonen V. Sairanen E. Parkkonen A. Abou Elseoud J. Kujala N. Forss CMC is more than a measure of corticospinal tract integrity in acute stroke patients NeuroImage: Clinical Afferent input Corticomuscular coherence Corticospinal tract integrity Magnetoencephalography Motor cortex Stroke |
author_facet |
R. Aikio K. Laaksonen V. Sairanen E. Parkkonen A. Abou Elseoud J. Kujala N. Forss |
author_sort |
R. Aikio |
title |
CMC is more than a measure of corticospinal tract integrity in acute stroke patients |
title_short |
CMC is more than a measure of corticospinal tract integrity in acute stroke patients |
title_full |
CMC is more than a measure of corticospinal tract integrity in acute stroke patients |
title_fullStr |
CMC is more than a measure of corticospinal tract integrity in acute stroke patients |
title_full_unstemmed |
CMC is more than a measure of corticospinal tract integrity in acute stroke patients |
title_sort |
cmc is more than a measure of corticospinal tract integrity in acute stroke patients |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2021-01-01 |
description |
In healthy subjects, motor cortex activity and electromyographic (EMG) signals from contracting contralateral muscle show coherence in the beta (15–30 Hz) range. Corticomuscular coherence (CMC) is considered a sign of functional coupling between muscle and brain. Based on prior studies, CMC is altered in stroke, but functional significance of this finding has remained unclear. Here, we examined CMC in acute stroke patients and correlated the results with clinical outcome measures and corticospinal tract (CST) integrity estimated with diffusion tensor imaging (DTI). During isometric contraction of the extensor carpi radialis muscle, EMG and magnetoencephalographic oscillatory signals were recorded from 29 patients with paresis of the upper extremity due to ischemic stroke and 22 control subjects. CMC amplitudes and peak frequencies at 13–30 Hz were compared between the two groups. In the patients, the peak frequency in both the affected and the unaffected hemisphere was significantly (p < 0.01) lower and the strength of CMC was significantly (p < 0.05) weaker in the affected hemisphere compared to the control subjects. The strength of CMC in the patients correlated with the level of tactile sensitivity and clinical test results of hand function. In contrast, no correlation between measures of CST integrity and CMC was found. The results confirm the earlier findings that CMC is altered in acute stroke and demonstrate that CMC is bidirectional and not solely a measure of integrity of the efferent corticospinal tract. |
topic |
Afferent input Corticomuscular coherence Corticospinal tract integrity Magnetoencephalography Motor cortex Stroke |
url |
http://www.sciencedirect.com/science/article/pii/S221315822100262X |
work_keys_str_mv |
AT raikio cmcismorethanameasureofcorticospinaltractintegrityinacutestrokepatients AT klaaksonen cmcismorethanameasureofcorticospinaltractintegrityinacutestrokepatients AT vsairanen cmcismorethanameasureofcorticospinaltractintegrityinacutestrokepatients AT eparkkonen cmcismorethanameasureofcorticospinaltractintegrityinacutestrokepatients AT aabouelseoud cmcismorethanameasureofcorticospinaltractintegrityinacutestrokepatients AT jkujala cmcismorethanameasureofcorticospinaltractintegrityinacutestrokepatients AT nforss cmcismorethanameasureofcorticospinaltractintegrityinacutestrokepatients |
_version_ |
1717373848171577344 |
spelling |
doaj-e561ec87eac64581a130d263ab7503f22021-09-21T04:09:10ZengElsevierNeuroImage: Clinical2213-15822021-01-0132102818CMC is more than a measure of corticospinal tract integrity in acute stroke patientsR. Aikio0K. Laaksonen1V. Sairanen2E. Parkkonen3A. Abou Elseoud4J. Kujala5N. Forss6Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Aalto NeuroImaging, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Department of Neurology, Helsinki University Hospital and Clinical Neurosciences, Neurology, University of Helsinki, P.O. Box 340, 00029 HUS, Helsinki, Finland; Corresponding author.Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Aalto NeuroImaging, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Department of Neurology, Helsinki University Hospital and Clinical Neurosciences, Neurology, University of Helsinki, P.O. Box 340, 00029 HUS, Helsinki, FinlandBABA Center, Department of Clinical Neurophysiology, Children’s Hospital, University of Helsinki and Helsinki University Hospital, P.O. Box 347, 00029 HUS, Helsinki, Finland; Department of Computer Science, University of Verona, 37134 Verona, ItalyDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Aalto NeuroImaging, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Department of Neurology, Helsinki University Hospital and Clinical Neurosciences, Neurology, University of Helsinki, P.O. Box 340, 00029 HUS, Helsinki, FinlandDepartment of Neuroradiology, University of Helsinki and Helsinki University Hospital, P.O. Box 340, 00029 HUS, Helsinki, FinlandDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Aalto NeuroImaging, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Department of Psychology, University of Jyväskylä, P.O. Box 35, 40014 Jyväskylä, FinlandDepartment of Neuroscience and Biomedical Engineering, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Aalto NeuroImaging, Aalto University School of Science, P.O. Box 12200, 00760 AALTO, Espoo, Finland; Department of Neurology, Helsinki University Hospital and Clinical Neurosciences, Neurology, University of Helsinki, P.O. Box 340, 00029 HUS, Helsinki, FinlandIn healthy subjects, motor cortex activity and electromyographic (EMG) signals from contracting contralateral muscle show coherence in the beta (15–30 Hz) range. Corticomuscular coherence (CMC) is considered a sign of functional coupling between muscle and brain. Based on prior studies, CMC is altered in stroke, but functional significance of this finding has remained unclear. Here, we examined CMC in acute stroke patients and correlated the results with clinical outcome measures and corticospinal tract (CST) integrity estimated with diffusion tensor imaging (DTI). During isometric contraction of the extensor carpi radialis muscle, EMG and magnetoencephalographic oscillatory signals were recorded from 29 patients with paresis of the upper extremity due to ischemic stroke and 22 control subjects. CMC amplitudes and peak frequencies at 13–30 Hz were compared between the two groups. In the patients, the peak frequency in both the affected and the unaffected hemisphere was significantly (p < 0.01) lower and the strength of CMC was significantly (p < 0.05) weaker in the affected hemisphere compared to the control subjects. The strength of CMC in the patients correlated with the level of tactile sensitivity and clinical test results of hand function. In contrast, no correlation between measures of CST integrity and CMC was found. The results confirm the earlier findings that CMC is altered in acute stroke and demonstrate that CMC is bidirectional and not solely a measure of integrity of the efferent corticospinal tract.http://www.sciencedirect.com/science/article/pii/S221315822100262XAfferent inputCorticomuscular coherenceCorticospinal tract integrityMagnetoencephalographyMotor cortexStroke |