Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ
Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that galectin-3 deficiency mice exhibit lupus-like autoim...
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Bibliographic Details
| Main Authors: |
Cristian Gabriel Beccaria,
María Carolina Amezcua Vesely,
Facundo Fiocca Vernengo,
Ricardo Carlos Gehrau,
María Cecilia Ramello,
Jimena Tosello Boari,
Melisa Gorosito Serrán,
Juan Mucci,
Eliane Piaggio,
Oscar Campetella,
Eva Virginia Acosta Rodríguez,
Carolina Lucía Montes,
Adriana Gruppi |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-04063-5
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