Electrical Characterisation of Aδ-Fibres Based on Human in vivo Electrostimulation Threshold
Electrical stimulation of small fibres is gaining attention in the diagnosis of peripheral neuropathies, such as diabetes mellitus, and pain research. However, it is still challenging to characterise the electrical characteristics of axons in small fibres (Aδ and C fibres). In particular, in vitro m...
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doaj-e5781da160294729aa50dd57a7dbd5992021-01-05T06:40:48ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-01-011410.3389/fnins.2020.588056588056Electrical Characterisation of Aδ-Fibres Based on Human in vivo Electrostimulation ThresholdShota Tanaka0Jose Gomez-Tames1Jose Gomez-Tames2Toshiaki Wasaka3Toshiaki Wasaka4Koji Inui5Koji Inui6Shoogo Ueno7Shoogo Ueno8Akimasa Hirata9Akimasa Hirata10Akimasa Hirata11Department of Electrical and Mechanical Engineering, Nagoya Institute of Technology, Nagoya, JapanDepartment of Electrical and Mechanical Engineering, Nagoya Institute of Technology, Nagoya, JapanCenter of Biomedical Physics and Information Technology, Nagoya Institute of Technology, Nagoya, JapanDepartment of Electrical and Mechanical Engineering, Nagoya Institute of Technology, Nagoya, JapanCenter of Biomedical Physics and Information Technology, Nagoya Institute of Technology, Nagoya, JapanDepartment of Functioning and Disability, Institute for Developmental Research, Aichi Developmental Disability Center, Kasugai, JapanDepartment of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, JapanCenter of Biomedical Physics and Information Technology, Nagoya Institute of Technology, Nagoya, JapanDepartment of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Electrical and Mechanical Engineering, Nagoya Institute of Technology, Nagoya, JapanCenter of Biomedical Physics and Information Technology, Nagoya Institute of Technology, Nagoya, JapanFrontier Research Institute for Information Science, Nagoya Institute of Technology, Nagoya, JapanElectrical stimulation of small fibres is gaining attention in the diagnosis of peripheral neuropathies, such as diabetes mellitus, and pain research. However, it is still challenging to characterise the electrical characteristics of axons in small fibres (Aδ and C fibres). In particular, in vitro measurement for human Aδ-fibre is difficult due to the presence of myelin and ethical reason. In this study, we investigate the in vivo electrical characteristics of the human Aδ-fibre to derive strength–duration (S–D) curves from the measurement. The Aδ-fibres are stimulated using coaxial planar electrodes with intraepidermal needle tip. For human volunteer experiments, the S–D curve of Aδ-fibre is obtained in terms of injected electrical current. With the computational analysis, the standard deviation of the S–D curve is mostly attributed to the thickness of the stratum corneum and depth of the needle tip, in addition to the fibre thickness. Then, we derive electrical parameters of the axon in the Aδ-fibre based on a conventional fibre model. The parameters derived here would be important in exploring the optimal stimulation condition of Aδ-fibres.https://www.frontiersin.org/articles/10.3389/fnins.2020.588056/fullstrength duration curveselective stimulation of small fibresextracellular electric fieldelectrical analysis in biological tissueselectrical stimulation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shota Tanaka Jose Gomez-Tames Jose Gomez-Tames Toshiaki Wasaka Toshiaki Wasaka Koji Inui Koji Inui Shoogo Ueno Shoogo Ueno Akimasa Hirata Akimasa Hirata Akimasa Hirata |
spellingShingle |
Shota Tanaka Jose Gomez-Tames Jose Gomez-Tames Toshiaki Wasaka Toshiaki Wasaka Koji Inui Koji Inui Shoogo Ueno Shoogo Ueno Akimasa Hirata Akimasa Hirata Akimasa Hirata Electrical Characterisation of Aδ-Fibres Based on Human in vivo Electrostimulation Threshold Frontiers in Neuroscience strength duration curve selective stimulation of small fibres extracellular electric field electrical analysis in biological tissues electrical stimulation |
author_facet |
Shota Tanaka Jose Gomez-Tames Jose Gomez-Tames Toshiaki Wasaka Toshiaki Wasaka Koji Inui Koji Inui Shoogo Ueno Shoogo Ueno Akimasa Hirata Akimasa Hirata Akimasa Hirata |
author_sort |
Shota Tanaka |
title |
Electrical Characterisation of Aδ-Fibres Based on Human in vivo Electrostimulation Threshold |
title_short |
Electrical Characterisation of Aδ-Fibres Based on Human in vivo Electrostimulation Threshold |
title_full |
Electrical Characterisation of Aδ-Fibres Based on Human in vivo Electrostimulation Threshold |
title_fullStr |
Electrical Characterisation of Aδ-Fibres Based on Human in vivo Electrostimulation Threshold |
title_full_unstemmed |
Electrical Characterisation of Aδ-Fibres Based on Human in vivo Electrostimulation Threshold |
title_sort |
electrical characterisation of aδ-fibres based on human in vivo electrostimulation threshold |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2021-01-01 |
description |
Electrical stimulation of small fibres is gaining attention in the diagnosis of peripheral neuropathies, such as diabetes mellitus, and pain research. However, it is still challenging to characterise the electrical characteristics of axons in small fibres (Aδ and C fibres). In particular, in vitro measurement for human Aδ-fibre is difficult due to the presence of myelin and ethical reason. In this study, we investigate the in vivo electrical characteristics of the human Aδ-fibre to derive strength–duration (S–D) curves from the measurement. The Aδ-fibres are stimulated using coaxial planar electrodes with intraepidermal needle tip. For human volunteer experiments, the S–D curve of Aδ-fibre is obtained in terms of injected electrical current. With the computational analysis, the standard deviation of the S–D curve is mostly attributed to the thickness of the stratum corneum and depth of the needle tip, in addition to the fibre thickness. Then, we derive electrical parameters of the axon in the Aδ-fibre based on a conventional fibre model. The parameters derived here would be important in exploring the optimal stimulation condition of Aδ-fibres. |
topic |
strength duration curve selective stimulation of small fibres extracellular electric field electrical analysis in biological tissues electrical stimulation |
url |
https://www.frontiersin.org/articles/10.3389/fnins.2020.588056/full |
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