ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity

ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity

Dynamic post-transcriptional control of RNA expression by RNA-binding proteins (RBPs) is critical during immune response. ZFP36 RBPs are prominent inflammatory regulators linked to autoimmunity and cancer, but functions in adaptive immunity are less clear. We used HITS-CLIP to define ZFP36 targets i...

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Bibliographic Details
Main Authors: Michael J Moore, Nathalie E Blachere, John J Fak, Christopher Y Park, Kirsty Sawicka, Salina Parveen, Ilana Zucker-Scharff, Bruno Moltedo, Alexander Y Rudensky, Robert B Darnell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
RNA binding protein
T cell
translation
anti-viral immunity
HITS-CLIP
Online Access:https://elifesciences.org/articles/33057

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