LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells
Breast cancer is an aggressive disease with a high incidence in women worldwide. Two decades ago, a controversial hypothesis was proposed that cancer arises from a subpopulation of “tumor initiating cells” or “cancer stem cells-like” (CSC). Today, CSC are defined as small subset of somatic cancer ce...
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doaj-e585f8c6504f4092b977edd2e4058b582021-03-04T00:06:50ZengMDPI AGBiomolecules2218-273X2021-03-011138038010.3390/biom11030380LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem CellsNadia Flores-Huerta0Macrina B. Silva-Cázares1Lourdes A. Arriaga-Pizano2Jessica L. Prieto-Chávez3César López-Camarillo4Laboratorio de Oncogenómica y Proteómica del Cáncer, Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, 03100 CDMX, MexicoDoctorado Institucional en Ingeniería y Ciencias de los Materiales, Universidad Autónoma de San Luis Potosí, 78210 San Luis Potosí, MexicoUnidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades del Centro Médico Siglo XXI, Instituto Mexicano del Seguro Social, 06720 CDMX, MexicoLaboratorio de Citometría de Flujo, Centro de Instrumentos, Coordinación de Investigación en Salud, Hospital de Especialidades del Centro Médico Siglo XXI, Instituto Mexicano del Seguro Social, 06720 CDMX, MexicoLaboratorio de Oncogenómica y Proteómica del Cáncer, Posgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, 03100 CDMX, MexicoBreast cancer is an aggressive disease with a high incidence in women worldwide. Two decades ago, a controversial hypothesis was proposed that cancer arises from a subpopulation of “tumor initiating cells” or “cancer stem cells-like” (CSC). Today, CSC are defined as small subset of somatic cancer cells within a tumor with self-renewal properties driven by the aberrant expression of genes involved in the maintenance of a stemness-like phenotype. The understanding of the underlying cellular and molecular mechanisms involved in the maintenance of CSC subpopulation are fundamental in the development and persistence of breast cancer. Nowadays, the hypothesis suggests that genetic and epigenetic alterations give rise to breast cancer stem cells (bCSC), which are responsible for self-renewal, tumor growth, chemoresistance, poor prognosis and low survival in patients. However, the prominence of bCSC, as well as the molecular mechanisms that regulates and promotes the malignant phenotypes, are still poorly understood. The role of non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) acting as oncogenes or tumor suppressor genes has been recently highlighted by a plethora of studies in breast cancer. These ncRNAs positively or negatively impact on different signaling pathways that govern the cancer hallmarks associated with bCSC, making them attractive targets for therapy. In this review, we present a current summary of the studies on the pivotal roles of lncRNAs and microRNAs in the regulation of genes associated to stemness of bCSC.https://www.mdpi.com/2218-273X/11/3/380breast cancercancer stem cellsmicroRNAslncRNAstherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nadia Flores-Huerta Macrina B. Silva-Cázares Lourdes A. Arriaga-Pizano Jessica L. Prieto-Chávez César López-Camarillo |
spellingShingle |
Nadia Flores-Huerta Macrina B. Silva-Cázares Lourdes A. Arriaga-Pizano Jessica L. Prieto-Chávez César López-Camarillo LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells Biomolecules breast cancer cancer stem cells microRNAs lncRNAs therapy |
author_facet |
Nadia Flores-Huerta Macrina B. Silva-Cázares Lourdes A. Arriaga-Pizano Jessica L. Prieto-Chávez César López-Camarillo |
author_sort |
Nadia Flores-Huerta |
title |
LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells |
title_short |
LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells |
title_full |
LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells |
title_fullStr |
LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells |
title_full_unstemmed |
LncRNAs and microRNAs as Essential Regulators of Stemness in Breast Cancer Stem Cells |
title_sort |
lncrnas and micrornas as essential regulators of stemness in breast cancer stem cells |
publisher |
MDPI AG |
series |
Biomolecules |
issn |
2218-273X |
publishDate |
2021-03-01 |
description |
Breast cancer is an aggressive disease with a high incidence in women worldwide. Two decades ago, a controversial hypothesis was proposed that cancer arises from a subpopulation of “tumor initiating cells” or “cancer stem cells-like” (CSC). Today, CSC are defined as small subset of somatic cancer cells within a tumor with self-renewal properties driven by the aberrant expression of genes involved in the maintenance of a stemness-like phenotype. The understanding of the underlying cellular and molecular mechanisms involved in the maintenance of CSC subpopulation are fundamental in the development and persistence of breast cancer. Nowadays, the hypothesis suggests that genetic and epigenetic alterations give rise to breast cancer stem cells (bCSC), which are responsible for self-renewal, tumor growth, chemoresistance, poor prognosis and low survival in patients. However, the prominence of bCSC, as well as the molecular mechanisms that regulates and promotes the malignant phenotypes, are still poorly understood. The role of non-coding RNAs (ncRNAs), such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) acting as oncogenes or tumor suppressor genes has been recently highlighted by a plethora of studies in breast cancer. These ncRNAs positively or negatively impact on different signaling pathways that govern the cancer hallmarks associated with bCSC, making them attractive targets for therapy. In this review, we present a current summary of the studies on the pivotal roles of lncRNAs and microRNAs in the regulation of genes associated to stemness of bCSC. |
topic |
breast cancer cancer stem cells microRNAs lncRNAs therapy |
url |
https://www.mdpi.com/2218-273X/11/3/380 |
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