Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD)
(1) Background<i>:</i> The etiology of non-alcoholic fatty liver disease (NAFLD) is multifactorial. Dietary composition has been implicated as a factor modulating intestinal barrier and could affect disease severity. The aim of this study was to evaluate dietary intake and markers of int...
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doaj-e58cd5daed5e404185523eb73a1479492020-11-25T03:01:45ZengMDPI AGNutrients2072-66432020-03-0112369910.3390/nu12030699nu12030699Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD)Anika Nier0Yvonne Huber1Christian Labenz2Maurice Michel3Ina Bergheim4Jörn M. Schattenberg5Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, 1090 Vienna, AustriaMetabolic Liver Research Program, I. Department of Medicine, University Medical Centre of the Johannes Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, GermanyMetabolic Liver Research Program, I. Department of Medicine, University Medical Centre of the Johannes Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, GermanyMetabolic Liver Research Program, I. Department of Medicine, University Medical Centre of the Johannes Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, GermanyDepartment of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, 1090 Vienna, AustriaMetabolic Liver Research Program, I. Department of Medicine, University Medical Centre of the Johannes Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, Germany(1) Background<i>:</i> The etiology of non-alcoholic fatty liver disease (NAFLD) is multifactorial. Dietary composition has been implicated as a factor modulating intestinal barrier and could affect disease severity. The aim of this study was to evaluate dietary intake and markers of intestinal permeability in patients with NAFLD. (2) Methods<i>: </i>We enrolled 63 patients with NAFLD and compared them to age-matched controls. (3) Results: body mass index (BMI) and leptin to adiponectin ratio—the latter being an indicator of abdominal fat accumulation—correlated with the degree of hepatic steatosis being accompanied with rising levels of fasting insulin. Furthermore, endotoxin plasma levels and markers of inflammation were significantly higher in NAFLD compared to controls and increased with the severity of hepatic steatosis. Despite comparable intake of total energy and macronutrients, intake of fiber was lower in all patients with NAFLD compared to controls and were negatively related to disease severity. (4) Conclusions: Taken together, results of the present study suggest that fiber intake in patients is negatively related to steatosis degree and bacterial endotoxin levels, further suggesting that dietary fiber intake may be a target in NAFLD treatment (NCT: 02366052 and 03482284).https://www.mdpi.com/2072-6643/12/3/699non-alcoholic fatty liver diseasedietary fiber consumptionbacterial endotoxinhepatic fibrosis |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anika Nier Yvonne Huber Christian Labenz Maurice Michel Ina Bergheim Jörn M. Schattenberg |
spellingShingle |
Anika Nier Yvonne Huber Christian Labenz Maurice Michel Ina Bergheim Jörn M. Schattenberg Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD) Nutrients non-alcoholic fatty liver disease dietary fiber consumption bacterial endotoxin hepatic fibrosis |
author_facet |
Anika Nier Yvonne Huber Christian Labenz Maurice Michel Ina Bergheim Jörn M. Schattenberg |
author_sort |
Anika Nier |
title |
Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD) |
title_short |
Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD) |
title_full |
Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD) |
title_fullStr |
Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD) |
title_full_unstemmed |
Adipokines and Endotoxemia Correlate with Hepatic Steatosis in Non-Alcoholic Fatty Liver Disease (NAFLD) |
title_sort |
adipokines and endotoxemia correlate with hepatic steatosis in non-alcoholic fatty liver disease (nafld) |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-03-01 |
description |
(1) Background<i>:</i> The etiology of non-alcoholic fatty liver disease (NAFLD) is multifactorial. Dietary composition has been implicated as a factor modulating intestinal barrier and could affect disease severity. The aim of this study was to evaluate dietary intake and markers of intestinal permeability in patients with NAFLD. (2) Methods<i>: </i>We enrolled 63 patients with NAFLD and compared them to age-matched controls. (3) Results: body mass index (BMI) and leptin to adiponectin ratio—the latter being an indicator of abdominal fat accumulation—correlated with the degree of hepatic steatosis being accompanied with rising levels of fasting insulin. Furthermore, endotoxin plasma levels and markers of inflammation were significantly higher in NAFLD compared to controls and increased with the severity of hepatic steatosis. Despite comparable intake of total energy and macronutrients, intake of fiber was lower in all patients with NAFLD compared to controls and were negatively related to disease severity. (4) Conclusions: Taken together, results of the present study suggest that fiber intake in patients is negatively related to steatosis degree and bacterial endotoxin levels, further suggesting that dietary fiber intake may be a target in NAFLD treatment (NCT: 02366052 and 03482284). |
topic |
non-alcoholic fatty liver disease dietary fiber consumption bacterial endotoxin hepatic fibrosis |
url |
https://www.mdpi.com/2072-6643/12/3/699 |
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