Hepatitis B virus infection in hilly/mountainous regions of southeastern China: a locality-dependent epidemiology
Abstract Background The overall prevalence of hepatitis B virus (HBV) infection in China is declining. The purpose of this study was to use a community-based epidemiological study to update the infection status of hepatitis B virus (HBV) in mountainous regions of China, and to evaluate the impact of...
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doaj-e59276eaa79945eeb629b13de8260a4e2020-11-25T03:51:37ZengBMCBMC Infectious Diseases1471-23342017-12-011711810.1186/s12879-017-2922-7Hepatitis B virus infection in hilly/mountainous regions of southeastern China: a locality-dependent epidemiologyPing Chen0Qinfen Xie1Ting Chen2Jiawei Wu3Jie Wu4Bing Ruan5Zhiqin Zhang6Hainv Gao7Lanjuan Li8Shulan (Hangzhou) Hospital, Zhejiang University International HospitalShulan (Hangzhou) Hospital, Zhejiang University International HospitalCollege of Medicine, Zhejiang UniversityCollege of Medicine, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityXianju Hospital of Traditional Chinese MedicineShulan (Hangzhou) Hospital, Zhejiang University International HospitalState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang UniversityAbstract Background The overall prevalence of hepatitis B virus (HBV) infection in China is declining. The purpose of this study was to use a community-based epidemiological study to update the infection status of hepatitis B virus (HBV) in mountainous regions of China, and to evaluate the impact of the Expanded Program of Immunization (EPI) on HBV transmission. Methods In total, 10,383 participants were selected by multi-stage stratified random cluster sampling in two mountainous regions, Xianju and Anji, in Zhejiang province, China. Results The positive rates of hepatitis B virus surface antigen (HBsAg), anti-HBV core antigen (anti-HBc), and anti-HBV surface antigen (anti-HBs) were 9.5%, 33.9%, and 51.0%, respectively. Positive HBV markers were more frequently detected in males than in females (P < 0.01). The alanine aminotransferase (ALT) levels were elevated (>38 IU/L) in 15.3% of the HBsAg-positive and 6.3% of the HBsAg-negative subjects. The α-fetoprotein (AFP) level was elevated in 0.8% of the HBsAg-positive participants who were older than 30 years old. Conclusions The epidemiology of HBV infection is location dependent. The prevalence of HBV infection in the mountainous regions is higher than the national levels. Moreover, HBV infection in women of childbearing age is up to 10%, which represents a main factor for continuous HBV transmission.http://link.springer.com/article/10.1186/s12879-017-2922-7Hepatitis B virusCommunity-based epidemiological studyExpanded program of immunizationContinuous HBV transmission |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ping Chen Qinfen Xie Ting Chen Jiawei Wu Jie Wu Bing Ruan Zhiqin Zhang Hainv Gao Lanjuan Li |
spellingShingle |
Ping Chen Qinfen Xie Ting Chen Jiawei Wu Jie Wu Bing Ruan Zhiqin Zhang Hainv Gao Lanjuan Li Hepatitis B virus infection in hilly/mountainous regions of southeastern China: a locality-dependent epidemiology BMC Infectious Diseases Hepatitis B virus Community-based epidemiological study Expanded program of immunization Continuous HBV transmission |
author_facet |
Ping Chen Qinfen Xie Ting Chen Jiawei Wu Jie Wu Bing Ruan Zhiqin Zhang Hainv Gao Lanjuan Li |
author_sort |
Ping Chen |
title |
Hepatitis B virus infection in hilly/mountainous regions of southeastern China: a locality-dependent epidemiology |
title_short |
Hepatitis B virus infection in hilly/mountainous regions of southeastern China: a locality-dependent epidemiology |
title_full |
Hepatitis B virus infection in hilly/mountainous regions of southeastern China: a locality-dependent epidemiology |
title_fullStr |
Hepatitis B virus infection in hilly/mountainous regions of southeastern China: a locality-dependent epidemiology |
title_full_unstemmed |
Hepatitis B virus infection in hilly/mountainous regions of southeastern China: a locality-dependent epidemiology |
title_sort |
hepatitis b virus infection in hilly/mountainous regions of southeastern china: a locality-dependent epidemiology |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2017-12-01 |
description |
Abstract Background The overall prevalence of hepatitis B virus (HBV) infection in China is declining. The purpose of this study was to use a community-based epidemiological study to update the infection status of hepatitis B virus (HBV) in mountainous regions of China, and to evaluate the impact of the Expanded Program of Immunization (EPI) on HBV transmission. Methods In total, 10,383 participants were selected by multi-stage stratified random cluster sampling in two mountainous regions, Xianju and Anji, in Zhejiang province, China. Results The positive rates of hepatitis B virus surface antigen (HBsAg), anti-HBV core antigen (anti-HBc), and anti-HBV surface antigen (anti-HBs) were 9.5%, 33.9%, and 51.0%, respectively. Positive HBV markers were more frequently detected in males than in females (P < 0.01). The alanine aminotransferase (ALT) levels were elevated (>38 IU/L) in 15.3% of the HBsAg-positive and 6.3% of the HBsAg-negative subjects. The α-fetoprotein (AFP) level was elevated in 0.8% of the HBsAg-positive participants who were older than 30 years old. Conclusions The epidemiology of HBV infection is location dependent. The prevalence of HBV infection in the mountainous regions is higher than the national levels. Moreover, HBV infection in women of childbearing age is up to 10%, which represents a main factor for continuous HBV transmission. |
topic |
Hepatitis B virus Community-based epidemiological study Expanded program of immunization Continuous HBV transmission |
url |
http://link.springer.com/article/10.1186/s12879-017-2922-7 |
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