Nociception and pain: lessons from optogenetics
The process of pain perception begins in the periphery by activation of nociceptors. From here nociceptive signals are conveyed via the dorsal horn of the spinal cord to multiple brain regions, where pain is perceived. Despite great progress in pain research in recent years, many questions remain re...
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Frontiers Media S.A.
2014-03-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00069/full |
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doaj-e59d360bbb4e4e9e809da5f92926a3182020-11-24T23:42:31ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-03-01810.3389/fnbeh.2014.0006977893Nociception and pain: lessons from optogeneticsVenetia eZachariou0Fiona eCarr1Icahn School of Medicine at Mount SinaiIcahn School of Medicine at Mount SinaiThe process of pain perception begins in the periphery by activation of nociceptors. From here nociceptive signals are conveyed via the dorsal horn of the spinal cord to multiple brain regions, where pain is perceived. Despite great progress in pain research in recent years, many questions remain regarding nociceptive circuitry and behavior, in both acute nociception and chronic pain states. Techniques that allow for selective activation of neuronal subpopulations in vivo can provide a better understanding of these complex pathways. Here we review the studies to date that have employed novel optogenetic tools to improve our understanding of the pain pathway at the peripheral, spinal and supraspinal levels.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00069/fullAmygdalaNociceptionOpsinsPainPrefrontal CortexSpinal Cord |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Venetia eZachariou Fiona eCarr |
spellingShingle |
Venetia eZachariou Fiona eCarr Nociception and pain: lessons from optogenetics Frontiers in Behavioral Neuroscience Amygdala Nociception Opsins Pain Prefrontal Cortex Spinal Cord |
author_facet |
Venetia eZachariou Fiona eCarr |
author_sort |
Venetia eZachariou |
title |
Nociception and pain: lessons from optogenetics |
title_short |
Nociception and pain: lessons from optogenetics |
title_full |
Nociception and pain: lessons from optogenetics |
title_fullStr |
Nociception and pain: lessons from optogenetics |
title_full_unstemmed |
Nociception and pain: lessons from optogenetics |
title_sort |
nociception and pain: lessons from optogenetics |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2014-03-01 |
description |
The process of pain perception begins in the periphery by activation of nociceptors. From here nociceptive signals are conveyed via the dorsal horn of the spinal cord to multiple brain regions, where pain is perceived. Despite great progress in pain research in recent years, many questions remain regarding nociceptive circuitry and behavior, in both acute nociception and chronic pain states. Techniques that allow for selective activation of neuronal subpopulations in vivo can provide a better understanding of these complex pathways. Here we review the studies to date that have employed novel optogenetic tools to improve our understanding of the pain pathway at the peripheral, spinal and supraspinal levels. |
topic |
Amygdala Nociception Opsins Pain Prefrontal Cortex Spinal Cord |
url |
http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00069/full |
work_keys_str_mv |
AT venetiaezachariou nociceptionandpainlessonsfromoptogenetics AT fionaecarr nociceptionandpainlessonsfromoptogenetics |
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1725504227436920832 |