Rapid Fabrication of Hydrogel Microstructures Using UV-Induced Projection Printing
Fabrication of hydrogel microstructures has attracted considerable attention. A large number of applications, such as fabricating tissue engineering scaffolds, delivering drugs to diseased tissue, and constructing extracellular matrix for studying cell behaviors, have been introduced. In this articl...
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doaj-e5ab45fde73846c9a7eac3e89bc05ed52020-11-25T00:55:20ZengMDPI AGMicromachines2072-666X2015-12-016121903191310.3390/mi6121464mi6121464Rapid Fabrication of Hydrogel Microstructures Using UV-Induced Projection PrintingWenguang Yang0Haibo Yu1Wenfeng Liang2Yuechao Wang3Lianqing Liu4State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, 114 Nanta Str., Shenhe Dist., Shenyang 110016, ChinaState Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, 114 Nanta Str., Shenhe Dist., Shenyang 110016, ChinaState Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, 114 Nanta Str., Shenhe Dist., Shenyang 110016, ChinaState Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, 114 Nanta Str., Shenhe Dist., Shenyang 110016, ChinaState Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, 114 Nanta Str., Shenhe Dist., Shenyang 110016, ChinaFabrication of hydrogel microstructures has attracted considerable attention. A large number of applications, such as fabricating tissue engineering scaffolds, delivering drugs to diseased tissue, and constructing extracellular matrix for studying cell behaviors, have been introduced. In this article, an ultraviolet (UV)-curing method based on a digital micromirror device (DMD) for fabricating poly(ethylene glycol) diacrylate (PEGDA) hydrogel microstructures was presented. By controlling UV projection in real-time using a DMD as digital dynamic mask instead of a physical mask, polymerization of the pre-polymer solution could be controlled to create custom-designed hydrogel microstructures. Arbitrary microstructures could also be fabricated within several seconds (<5 s) using a single-exposure, providing a much higher efficiency than existing methods, while also offering a high degree of flexibility and repeatability. Moreover, different cell chains, which can be used for straightforwardly and effectively studying the cell interaction, were formed by fabricated PEGDA microstructures.http://www.mdpi.com/2072-666X/6/12/1464microstructure fabricationpolymersspatial light modulatorscell chains |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenguang Yang Haibo Yu Wenfeng Liang Yuechao Wang Lianqing Liu |
spellingShingle |
Wenguang Yang Haibo Yu Wenfeng Liang Yuechao Wang Lianqing Liu Rapid Fabrication of Hydrogel Microstructures Using UV-Induced Projection Printing Micromachines microstructure fabrication polymers spatial light modulators cell chains |
author_facet |
Wenguang Yang Haibo Yu Wenfeng Liang Yuechao Wang Lianqing Liu |
author_sort |
Wenguang Yang |
title |
Rapid Fabrication of Hydrogel Microstructures Using UV-Induced Projection Printing |
title_short |
Rapid Fabrication of Hydrogel Microstructures Using UV-Induced Projection Printing |
title_full |
Rapid Fabrication of Hydrogel Microstructures Using UV-Induced Projection Printing |
title_fullStr |
Rapid Fabrication of Hydrogel Microstructures Using UV-Induced Projection Printing |
title_full_unstemmed |
Rapid Fabrication of Hydrogel Microstructures Using UV-Induced Projection Printing |
title_sort |
rapid fabrication of hydrogel microstructures using uv-induced projection printing |
publisher |
MDPI AG |
series |
Micromachines |
issn |
2072-666X |
publishDate |
2015-12-01 |
description |
Fabrication of hydrogel microstructures has attracted considerable attention. A large number of applications, such as fabricating tissue engineering scaffolds, delivering drugs to diseased tissue, and constructing extracellular matrix for studying cell behaviors, have been introduced. In this article, an ultraviolet (UV)-curing method based on a digital micromirror device (DMD) for fabricating poly(ethylene glycol) diacrylate (PEGDA) hydrogel microstructures was presented. By controlling UV projection in real-time using a DMD as digital dynamic mask instead of a physical mask, polymerization of the pre-polymer solution could be controlled to create custom-designed hydrogel microstructures. Arbitrary microstructures could also be fabricated within several seconds (<5 s) using a single-exposure, providing a much higher efficiency than existing methods, while also offering a high degree of flexibility and repeatability. Moreover, different cell chains, which can be used for straightforwardly and effectively studying the cell interaction, were formed by fabricated PEGDA microstructures. |
topic |
microstructure fabrication polymers spatial light modulators cell chains |
url |
http://www.mdpi.com/2072-666X/6/12/1464 |
work_keys_str_mv |
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