Milk Containing A2 β-Casein ONLY, as a Single Meal, Causes Fewer Symptoms of Lactose Intolerance than Milk Containing A1 and A2 β-Caseins in Subjects with Lactose Maldigestion and Intolerance: A Randomized, Double-Blind, Crossover Trial

• Main Authors: Monica Ramakrishnan, Tracy K. Eaton, Omer M. Sermet, Dennis A. Savaiano
• Format: Article
• Language: English
• Published: MDPI AG 2020-12-01
• Series: Nutrients
• Subjects: A1 beta-casein; A2 beta-casein; beta-casomorphin; gastrointestinal intolerance; hydrogen breath test; lactose challenge
• Online Access: https://www.mdpi.com/2072-6643/12/12/3855

Acute-feeding and multiple-day studies have demonstrated that milk containing A2 β-casein only causes fewer symptoms of lactose intolerance (LI) than milk containing both A1 and A2 β-caseins. We conducted a single-meal study to evaluate the gastrointestinal (GI) tolerance of milk containing different concentrations of A1 and A2 β-casein proteins. This was a randomized, double-blind, crossover trial in 25 LI subjects with maldigestion and an additional eight lactose maldigesters who did not meet the QLCSS criteria. Subjects received each of four types of milk (milk containing A2 β-casein protein only, Jersey milk, conventional milk, and lactose-free milk) after overnight fasting. Symptoms of GI intolerance and breath hydrogen concentrations were analyzed for 6 h after ingestion of each type of milk. In an analysis of the 25 LI subjects, total symptom score for abdominal pain was lower following consumption of milk containing A2 β-casein only, compared with conventional milk (<i>p</i> = 0.004). Post hoc analysis with lactose maldigesters revealed statistically significantly improved symptom scores (<i>p</i> = 0.04) and lower hydrogen production (<i>p</i> = 0.04) following consumption of milk containing A2 β-casein only compared with conventional milk. Consumption of milk containing A2 β-casein only is associated with fewer GI symptoms than consumption of conventional milk in lactose maldigesters.