Heme Cytotoxicity And The Pathogenesis of Immune Mediated Inflammatory Diseases.
Heme, iron (Fe) protoporphyrin IX, functions as a prosthetic group in a range of hemoproteins essential to support life under aerobic conditions. The Fe contained within the prosthetic heme groups of these hemoproteins can catalyze the production of cytotoxic reactive oxygen species (ROS). Presumabl...
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doaj-e5c71498e8bf451b8c1294aefc7f18af2020-11-24T22:49:16ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122012-05-01310.3389/fphar.2012.0007723719Heme Cytotoxicity And The Pathogenesis of Immune Mediated Inflammatory Diseases.Rasmus eLarsen0Zélia eGouveia1Miguel P Soares2Raffaella eGozzelino3Instituto Gulbenkian de CiênciaInstituto Gulbenkian de CiênciaInstituto Gulbenkian de CiênciaInstituto Gulbenkian de CiênciaHeme, iron (Fe) protoporphyrin IX, functions as a prosthetic group in a range of hemoproteins essential to support life under aerobic conditions. The Fe contained within the prosthetic heme groups of these hemoproteins can catalyze the production of cytotoxic reactive oxygen species (ROS). Presumably for this reason, heme must be sequestered within those hemoproteins, thereby shielding the reactivity of its Fe-heme. However, under pathologic conditions associated with oxidative stress, some hemoproteins can release their prosthetic heme groups. While this heme is not necessarily damaging per se, it becomes highly cytotoxic in the presence of a range of inflammatory mediators such as tumor necrosis factor (TNF). This can lead to tissue damage and, as such, exacerbate the pathologic outcome of several immune mediated inflammatory conditions. Presumably, targeting free heme may be used as a therapeutic intervention against these diseases.http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00077/fullHemeheme oxygenaseCytotoxicityprogrammed cell deathimmune mediated inflammatory diseases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rasmus eLarsen Zélia eGouveia Miguel P Soares Raffaella eGozzelino |
spellingShingle |
Rasmus eLarsen Zélia eGouveia Miguel P Soares Raffaella eGozzelino Heme Cytotoxicity And The Pathogenesis of Immune Mediated Inflammatory Diseases. Frontiers in Pharmacology Heme heme oxygenase Cytotoxicity programmed cell death immune mediated inflammatory diseases |
author_facet |
Rasmus eLarsen Zélia eGouveia Miguel P Soares Raffaella eGozzelino |
author_sort |
Rasmus eLarsen |
title |
Heme Cytotoxicity And The Pathogenesis of Immune Mediated Inflammatory Diseases. |
title_short |
Heme Cytotoxicity And The Pathogenesis of Immune Mediated Inflammatory Diseases. |
title_full |
Heme Cytotoxicity And The Pathogenesis of Immune Mediated Inflammatory Diseases. |
title_fullStr |
Heme Cytotoxicity And The Pathogenesis of Immune Mediated Inflammatory Diseases. |
title_full_unstemmed |
Heme Cytotoxicity And The Pathogenesis of Immune Mediated Inflammatory Diseases. |
title_sort |
heme cytotoxicity and the pathogenesis of immune mediated inflammatory diseases. |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2012-05-01 |
description |
Heme, iron (Fe) protoporphyrin IX, functions as a prosthetic group in a range of hemoproteins essential to support life under aerobic conditions. The Fe contained within the prosthetic heme groups of these hemoproteins can catalyze the production of cytotoxic reactive oxygen species (ROS). Presumably for this reason, heme must be sequestered within those hemoproteins, thereby shielding the reactivity of its Fe-heme. However, under pathologic conditions associated with oxidative stress, some hemoproteins can release their prosthetic heme groups. While this heme is not necessarily damaging per se, it becomes highly cytotoxic in the presence of a range of inflammatory mediators such as tumor necrosis factor (TNF). This can lead to tissue damage and, as such, exacerbate the pathologic outcome of several immune mediated inflammatory conditions. Presumably, targeting free heme may be used as a therapeutic intervention against these diseases. |
topic |
Heme heme oxygenase Cytotoxicity programmed cell death immune mediated inflammatory diseases |
url |
http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00077/full |
work_keys_str_mv |
AT rasmuselarsen hemecytotoxicityandthepathogenesisofimmunemediatedinflammatorydiseases AT zeliaegouveia hemecytotoxicityandthepathogenesisofimmunemediatedinflammatorydiseases AT miguelpsoares hemecytotoxicityandthepathogenesisofimmunemediatedinflammatorydiseases AT raffaellaegozzelino hemecytotoxicityandthepathogenesisofimmunemediatedinflammatorydiseases |
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